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Hematopoietically expressed homeobox

PDB rendering based on 2e1o.
Available structures
External IDs OMIM604420 MGI96086 HomoloGene31110 GeneCards: HHEX Gene
RNA expression pattern
PBB GE HHEX 204689 at tn.png
PBB GE HHEX 215933 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3087 15242
Ensembl ENSG00000152804 n/a
UniProt Q03014 n/a
RefSeq (mRNA) NM_002729 NM_008245
RefSeq (protein) NP_002720 NP_032271
Location (UCSC) Chr 10:
94.44 - 94.45 Mb
PubMed search [1] [2]

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene.[1][2][3]

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.[3]



HHEX has been shown to interact with Promyelocytic leukemia protein.[4]


  1. ^ Bedford FK, Ashworth A, Enver T, Wiedemann LM (May 1993). "HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human". Nucleic Acids Res 21 (5): 1245–9. PMID 8096636.  
  2. ^ Hromas R, Radich J, Collins S (Oct 1993). "PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells". Biochem Biophys Res Commun 195 (2): 976–83. doi:10.1006/bbrc.1993.2140. PMID 8103988.  
  3. ^ a b "Entrez Gene: HHEX hematopoietically expressed homeobox".  
  4. ^ Topcu, Z; Mack D L, Hromas R A, Borden K L (Nov. 1999). "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control". Oncogene (ENGLAND) 18 (50): 7091–100. doi:10.1038/sj.onc.1203201. ISSN 0950-9232. PMID 10597310.  

Further reading

  • Neidle S, Goodwin GH (1994). "A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells.". FEBS Lett. 345 (2-3): 93–8. doi:10.1016/0014-5793(94)00446-3. PMID 7911091.  
  • Crompton MR, Bartlett TJ, MacGregor AD, et al. (1993). "Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.". Nucleic Acids Res. 20 (21): 5661–7. doi:10.1093/nar/20.21.5661. PMID 1360645.  
  • Manfioletti G, Gattei V, Buratti E, et al. (1995). "Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells.". Blood 85 (5): 1237–45. PMID 7858254.  
  • Topcu Z, Mack DL, Hromas RA, Borden KL (2000). "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.". Oncogene 18 (50): 7091–100. doi:10.1038/sj.onc.1203201. PMID 10597310.  
  • Pellizzari L, D'Elia A, Rustighi A, et al. (2000). "Expression and function of the homeodomain-containing protein Hex in thyroid cells.". Nucleic Acids Res. 28 (13): 2503–11. doi:10.1093/nar/28.13.2503. PMID 10871399.  
  • Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins.". J. Biol. Chem. 276 (46): 43074–82. doi:10.1074/jbc.M102552200. PMID 11551904.  
  • Morgutti M, Demori E, Pecile V, et al. (2001). "Genomic organization and chromosome mapping of the human homeobox gene HHEX.". Cytogenet. Cell Genet. 94 (1-2): 30–2. doi:10.1159/000048778. PMID 11701950.  
  • D'Elia AV, Tell G, Russo D, et al. (2002). "Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors.". J. Clin. Endocrinol. Metab. 87 (3): 1376–83. doi:10.1210/jc.87.3.1376. PMID 11889211.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Topisirovic I, Culjkovic B, Cohen N, et al. (2003). "The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.". EMBO J. 22 (3): 689–703. doi:10.1093/emboj/cdg069. PMID 12554669.  
  • Nakagawa T, Abe M, Yamazaki T, et al. (2003). "HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro.". Arterioscler. Thromb. Vasc. Biol. 23 (2): 231–7. doi:10.1161/01.ATV.0000052670.55321.87. PMID 12588764.  
  • Puppin C, D'Elia AV, Pellizzari L, et al. (2003). "Thyroid-specific transcription factors control Hex promoter activity.". Nucleic Acids Res. 31 (7): 1845–52. doi:10.1093/nar/gkg295. PMID 12655000.  
  • Bess KL, Swingler TE, Rivett AJ, et al. (2003). "The transcriptional repressor protein PRH interacts with the proteasome.". Biochem. J. 374 (Pt 3): 667–75. doi:10.1042/BJ20030769. PMID 12826010.  
  • George A, Morse HC, Justice MJ (2003). "The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells.". Oncogene 22 (43): 6764–73. doi:10.1038/sj.onc.1206822. PMID 14555989.  
  • Minami T, Murakami T, Horiuchi K, et al. (2004). "Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.". J. Biol. Chem. 279 (20): 20626–35. doi:10.1074/jbc.M308730200. PMID 15016828.  
  • Puppin C, Presta I, D'Elia AV, et al. (2004). "Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter.". Mol. Cell. Endocrinol. 214 (1-2): 117–25. doi:10.1016/j.mce.2003.10.061. PMID 15062550.  
  • Swingler TE, Bess KL, Yao J, et al. (2004). "The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells.". J. Biol. Chem. 279 (33): 34938–47. doi:10.1074/jbc.M404488200. PMID 15187083.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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