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Hypermethylated in cancer 1
Symbols HIC1; ZBTB29; hic-1
External IDs OMIM603825 MGI1338010 HomoloGene4740 GeneCards: HIC1 Gene
RNA expression pattern
PBB GE HIC1 208461 at tn.png
More reference expression data
Species Human Mouse
Entrez 3090 15248
Ensembl ENSG00000177374 ENSMUSG00000043099
UniProt Q14526 Q5NCQ8
RefSeq (mRNA) NM_006497 XM_001000715
RefSeq (protein) NP_006488 XP_001000715
Location (UCSC) Chr 17:
1.91 - 1.91 Mb
Chr 11:
74.98 - 74.99 Mb
PubMed search [1] [2]

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.[1]


Further reading

  • Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]". Med Sci (Paris) 22 (1): 54–61. PMID 16386221.  
  • Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.". Nat. Med. 1 (6): 570–7. doi:10.1038/nm0695-570. PMID 7585125.  
  • Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer.". Oncogene 16 (16): 2159–64. doi:10.1038/sj.onc.1201976. PMID 9572497.  
  • Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved.". Biochim. Biophys. Acta 1443 (1-2): 230–2. PMID 9838134.  
  • Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831–6. doi:10.1073/pnas.96.26.14831. PMID 10611298.  
  • Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53.". J. Biol. Chem. 276 (5): 3078–89. doi:10.1074/jbc.M008690200. PMID 11073960.  
  • Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1.". Biochem. Biophys. Res. Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.  
  • Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.". Mol. Cell. Biol. 22 (13): 4890–901. doi:10.1128/MCB.22.13.4890-4901.2002. PMID 12052894.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMID 12621583.  
  • Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms.". Clin. Cancer Res. 9 (10 Pt 1): 3674–8. PMID 14506157.  
  • Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas.". J. Neuropathol. Exp. Neurol. 62 (11): 1192–201. PMID 14656076.  
  • Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.". Carcinogenesis 25 (5): 661–8. doi:10.1093/carcin/bgh055. PMID 14688019.  
  • Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.". Oncogene 23 (22): 4023–31. doi:10.1038/sj.onc.1207504. PMID 15007385.  
  • Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.". J. Biol. Chem. 279 (37): 38313–24. doi:10.1074/jbc.M401610200. PMID 15231840.  
  • Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.". Cancer Cell 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761.  
  • Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1.". Oncogene 25 (14): 2030–9. doi:10.1038/sj.onc.1209240. PMID 16301995.  
  • Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.". Embo J. 25 (11): 2326–37. doi:10.1038/sj.emboj.7601147. PMID 16724116.  
  • Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP.". Febs J. 273 (13): 2879–90. doi:10.1111/j.1742-4658.2006.05301.x. PMID 16762039.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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