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Hypoxia inducible factor 3, alpha subunit
Symbols HIF3A; HIF-3A; HIF-3A4; IPAS; MOP7; PASD7
External IDs OMIM609976 MGI1859778 HomoloGene9646 GeneCards: HIF3A Gene
RNA expression pattern
PBB GE HIF3A 222123 s at tn.png
PBB GE HIF3A 219319 at tn.png
More reference expression data
Species Human Mouse
Entrez 64344 53417
Ensembl ENSG00000124440 n/a
UniProt n/a n/a
RefSeq (mRNA) NM_022462 XM_989804
RefSeq (protein) NP_071907 XP_994898
Location (UCSC) Chr 19:
51.49 - 51.54 Mb
PubMed search [1] [2]

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.[1][2][3]

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.[3]

See also


  1. ^ Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (Sep 2001). "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha". Biochem Biophys Res Commun 287 (4): 808-13. doi:10.1006/bbrc.2001.5659. PMID 11573933.  
  2. ^ Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L (Dec 2001). "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression". Nature 414 (6863): 550-4. doi:10.1038/35107085. PMID 11734856.  
  3. ^ a b "Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit".  

Further reading

  • Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA. (1998). "Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.". Gene Expr. 7 (3): 205–13. PMID 9840812.  
  • Makino Y, Kanopka A, Wilson WJ, et al. (2002). "Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus.". J. Biol. Chem. 277 (36): 32405–8. doi:10.1074/jbc.C200328200. PMID 12119283.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Maynard MA, Qi H, Chung J, et al. (2003). "Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.". J. Biol. Chem. 278 (13): 11032–40. doi:10.1074/jbc.M208681200. PMID 12538644.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Maynard MA, Evans AJ, Hosomi T, et al. (2006). "Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.". FASEB J. 19 (11): 1396–406. doi:10.1096/fj.05-3788com. PMID 16126907.  
  • Jang MS, Park JE, Lee JA, et al. (2005). "Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins.". Biochem. Biophys. Res. Commun. 337 (1): 209–15. doi:10.1016/j.bbrc.2005.09.038. PMID 16182248.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Li QF, Wang XR, Yang YW, Lin H (2006). "Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.". Cell Res. 16 (6): 548–58. doi:10.1038/ PMID 16775626.  
  • Kollers S, Musilova P, Rubes J, Rocha D (2007). "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13.". Anim. Genet. 37 (6): 595–6. doi:10.1111/j.1365-2052.2006.01516.x. PMID 17121608.  


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