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HIV-associated lipodystrophy: Wikis


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HIV-associated lipodystrophy
Classification and external resources
MeSH D039682

HIV-associated lipodystrophy is a skin condition characterized by loss of subcutaneous fat associated with infection with HIV.[1]:497



Although the exact mechanism of HIV-associated lipodystrophy is not fully elucidated, it is believed to be caused by anti-retroviral medications. Lipodystrophy seems to be mainly due to HIV-1 protease inhibitors. Interference with lipid metabolism is postulated as pathophysiology. Also, the development of lipodystrophy is associated with specific nucleoside reverse transcriptase inhibitors (NRTI). Mitochondrial toxicity is postulated to be involved in the pathogenesis associated with NRTI[2]

Presentations include

HIV-associated lipodystrophy commonly presents with fat loss in face, buttocks, arms, legs

There is also fat accumulation caused by these drugs in various body parts. Patients often present with "buffalo hump" like fat deposits in their upper backs. Breast sizes of patients (both male and female) tends to increase. In addition, patients develop abdominal obesity, commonly described as a "beer gut".


Reversion of lipodystrophy does not occur after withdrawal of protease inhibitors.[2]

See also


  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.  
  2. ^ a b Martinez E, Mocroft A, García-Viejo MA, et al. (February 2001). "Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study". Lancet 357 (9256): 592–8. doi:10.1016/S0140-6736(00)04056-3. PMID 11558485.  


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