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Human immunodeficiency virus type I enhancer binding protein 2
Symbols HIVEP2; HIV-EP2; MBP-2; MIBP1
External IDs OMIM143054 MGI1338076 HomoloGene4900 GeneCards: HIVEP2 Gene
RNA expression pattern
PBB GE HIVEP2 212642 s at tn.png
PBB GE HIVEP2 212641 at tn.png
More reference expression data
Species Human Mouse
Entrez 3097 15273
Ensembl ENSG00000010818 ENSMUSG00000015501
UniProt P31629 Q3UHF7
RefSeq (mRNA) NM_006734 NM_010437
RefSeq (protein) NP_006725 NP_034567
Location (UCSC) Chr 6:
143.11 - 143.31 Mb
Chr 10:
13.66 - 13.84 Mb
PubMed search [1] [2]

Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.[1][2][3]

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][3]


  1. ^ Sudo T, Ozawa K, Soeda EI, Nomura N, Ishii S (Mar 1992). "Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24". Genomics 12 (1): 167-70. PMID 1733857.  
  2. ^ Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S, Ishii S (Jun 1991). "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1". J Biol Chem 266 (13): 8590-4. PMID 2022670.  
  3. ^ a b "Entrez Gene: HIVEP2 human immunodeficiency virus type I enhancer binding protein 2".  

Further reading

  • van 't Veer LJ, Lutz PM, Isselbacher KJ, Bernards R (1992). "Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes.". Proc. Natl. Acad. Sci. U.S.A. 89 (19): 8971–5. doi:10.1073/pnas.89.19.8971. PMID 1409593.  
  • Rustgi AK, Van 't Veer LJ, Bernards R (1991). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8707–10. doi:10.1073/pnas.87.22.8707. PMID 2247438.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Dörflinger U, Pscherer A, Moser M, et al. (1999). "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain.". Mol. Cell. Biol. 19 (5): 3736–47. PMID 10207097.  
  • Zajac-Kaye M, Ben-Baruch N, Kastanos E, et al. (2000). "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.". Biochem. J. 345 Pt 3: 535–41. doi:10.1042/0264-6021:3450535. PMID 10642512.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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