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Human immunodeficiency virus type I enhancer binding protein 3
Symbols HIVEP3; FLJ16752; KBP-1; KBP1; KIAA1555; KRC; ZAS3
External IDs OMIM606649 MGI106589 HomoloGene7803 GeneCards: HIVEP3 Gene
RNA expression pattern
PBB GE HIVEP3 220042 x at tn.png
More reference expression data
Species Human Mouse
Entrez 59269 16656
Ensembl ENSG00000127124 ENSMUSG00000028634
UniProt n/a n/a
RefSeq (mRNA) NM_024503 XM_987411
RefSeq (protein) NP_078779 XP_992505
Location (UCSC) Chr 1:
41.74 - 42.16 Mb
Chr 4:
119.31 - 119.63 Mb
PubMed search [1] [2]

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.[1][2]

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][2]



HIVEP3 has been shown to interact with TRAF1[3] and TRAF2.[3]


  1. ^ Hicar MD, Liu Y, Allen CE, Wu LC (Feb 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID 11161801.  
  2. ^ a b "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".  
  3. ^ a b Oukka, Mohamed; Kim Sean T, Lugo Geancarlo, Sun Jenny, Wu Lai-Chu, Glimcher Laurie H (Jan. 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Mol. Cell (United States) 9 (1): 121–31. ISSN 1097-2765. PMID 11804591.  

Further reading

  • Rustgi AK, Van 't Veer LJ, Bernards R (1991). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8707–10. doi:10.1073/pnas.87.22.8707. PMID 2247438.  
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. PMID 10997877.  
  • Oukka M, Kim ST, Lugo G, et al. (2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.". Mol. Cell 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Oukka M, Wein MN, Glimcher LH (2004). "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.". J. Exp. Med. 199 (1): 15–24. doi:10.1084/jem.20030421. PMID 14707112.  
  • Qin H, Wang J, Liang Y, et al. (2004). "RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2.". Nucleic Acids Res. 32 (4): 1492–501. doi:10.1093/nar/gkh295. PMID 14999091.  
  • Hong JW, Wu LC (2005). "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes.". Biochim. Biophys. Acta 1681 (2-3): 74–87. doi:10.1016/j.bbaexp.2004.10.004. PMID 15627499.  
  • Bettelli E, Dastrange M, Oukka M (2005). "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (14): 5138–43. doi:10.1073/pnas.0501675102. PMID 15790681.  
  • Li YJ, Deng J, Mayhew GM, et al. (2007). "Investigation of the PARK10 gene in Parkinson disease.". Ann. Hum. Genet. 71 (Pt 5): 639–47. doi:10.1111/j.1469-1809.2007.00353.x. PMID 17388942.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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