The Full Wiki

More info on HLF (gene)

HLF (gene): Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Hepatic leukemia factor
Identifiers
Symbols HLF; MGC33822
External IDs OMIM142385 MGI96108 HomoloGene31074 GeneCards: HLF Gene
RNA expression pattern
PBB GE HLF 204753 s at tn.png
PBB GE HLF 204754 at tn.png
PBB GE HLF 204755 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3131 217082
Ensembl ENSG00000108924 ENSMUSG00000003949
UniProt Q16534 Q5SR29
RefSeq (mRNA) NM_002126 NM_172563
RefSeq (protein) NP_002117 NP_766151
Location (UCSC) Chr 17:
50.7 - 50.76 Mb
Chr 11:
90.15 - 90.21 Mb
PubMed search [1] [2]

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]

References

  1. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (Aug 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science 257 (5069): 531-4. PMID 1386162.  
  2. ^ a b "Entrez Gene: HLF hepatic leukemia factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3131.  

Further reading

  • LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia.". Front. Biosci. 8: s206–22. doi:10.2741/1030. PMID 12700034.  
  • Hunger SP, Ohyashiki K, Toyama K, Cleary ML (1992). "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.". Genes Dev. 6 (9): 1608–20. doi:10.1101/gad.6.9.1608. PMID 1516826.  
  • Falvey E, Fleury-Olela F, Schibler U (1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.". Embo J. 14 (17): 4307–17. PMID 7556072.  
  • Hunger SP, Brown R, Cleary ML (1994). "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.". Mol. Cell. Biol. 14 (9): 5986–96. PMID 8065331.  
  • Inaba T, Shapiro LH, Funabiki T, et al. (1994). "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.". Mol. Cell. Biol. 14 (5): 3403–13. PMID 8164688.  
  • Hunger SP (1996). "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis.". Blood 87 (4): 1211–24. PMID 8608207.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.". Blood 87 (11): 4607–17. PMID 8639829.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Takahata S, Sogawa K, Kobayashi A, et al. (1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.". Biochem. Biophys. Res. Commun. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.  
  • Inukai T, Inaba T, Ikushima S, Look AT (1998). "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.". Mol. Cell. Biol. 18 (10): 6035–43. PMID 9742120.  
  • Begbie M, Mueller C, Lillicrap D (1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes.". DNA Cell Biol. 18 (2): 165–73. doi:10.1089/104454999315556. PMID 10073576.  
  • Ema M, Hirota K, Mimura J, et al. (1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.". Embo J. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMID 10202154.  
  • Honda H, Inaba T, Suzuki T, et al. (1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.". Blood 93 (9): 2780–90. PMID 10216071.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsunaga T, Inaba T, Matsui H, et al. (2004). "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.". Blood 103 (8): 3185–91. doi:10.1182/blood-2003-09-3022. PMID 15070701.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message