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HLF (gene): Wikis


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Hepatic leukemia factor
Symbols HLF; MGC33822
External IDs OMIM142385 MGI96108 HomoloGene31074 GeneCards: HLF Gene
RNA expression pattern
PBB GE HLF 204753 s at tn.png
PBB GE HLF 204754 at tn.png
PBB GE HLF 204755 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3131 217082
Ensembl ENSG00000108924 ENSMUSG00000003949
UniProt Q16534 Q5SR29
RefSeq (mRNA) NM_002126 NM_172563
RefSeq (protein) NP_002117 NP_766151
Location (UCSC) Chr 17:
50.7 - 50.76 Mb
Chr 11:
90.15 - 90.21 Mb
PubMed search [1] [2]

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]


  1. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (Aug 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science 257 (5069): 531-4. PMID 1386162.  
  2. ^ a b "Entrez Gene: HLF hepatic leukemia factor".  

Further reading

  • LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia.". Front. Biosci. 8: s206–22. doi:10.2741/1030. PMID 12700034.  
  • Hunger SP, Ohyashiki K, Toyama K, Cleary ML (1992). "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.". Genes Dev. 6 (9): 1608–20. doi:10.1101/gad.6.9.1608. PMID 1516826.  
  • Falvey E, Fleury-Olela F, Schibler U (1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.". Embo J. 14 (17): 4307–17. PMID 7556072.  
  • Hunger SP, Brown R, Cleary ML (1994). "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.". Mol. Cell. Biol. 14 (9): 5986–96. PMID 8065331.  
  • Inaba T, Shapiro LH, Funabiki T, et al. (1994). "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.". Mol. Cell. Biol. 14 (5): 3403–13. PMID 8164688.  
  • Hunger SP (1996). "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis.". Blood 87 (4): 1211–24. PMID 8608207.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.". Blood 87 (11): 4607–17. PMID 8639829.  
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Takahata S, Sogawa K, Kobayashi A, et al. (1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.". Biochem. Biophys. Res. Commun. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.  
  • Inukai T, Inaba T, Ikushima S, Look AT (1998). "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.". Mol. Cell. Biol. 18 (10): 6035–43. PMID 9742120.  
  • Begbie M, Mueller C, Lillicrap D (1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes.". DNA Cell Biol. 18 (2): 165–73. doi:10.1089/104454999315556. PMID 10073576.  
  • Ema M, Hirota K, Mimura J, et al. (1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.". Embo J. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMID 10202154.  
  • Honda H, Inaba T, Suzuki T, et al. (1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.". Blood 93 (9): 2780–90. PMID 10216071.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsunaga T, Inaba T, Matsui H, et al. (2004). "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.". Blood 103 (8): 3185–91. doi:10.1182/blood-2003-09-3022. PMID 15070701.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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