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HMGB1: Wikis


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High-mobility group box 1

PDB rendering based on 1aab.
Available structures
1aab, 1ckt, 1hme, 1hmf, 1hsm, 1hsn, 1j3x, 1nhm, 1nhn
Symbols HMGB1; DKFZp686A04236; HMG1; HMG3; SBP-1
External IDs OMIM163905 MGI96113 HomoloGene55511 GeneCards: HMGB1 Gene
RNA expression pattern
PBB GE HMGB1 200679 x at tn.png
PBB GE HMGB1 200680 x at tn.png
PBB GE HMGB1 214938 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3146 15289
Ensembl ENSG00000189403 n/a
UniProt P09429 n/a
RefSeq (mRNA) NM_002128 NM_010439
RefSeq (protein) NP_002119 NP_034569
Location (UCSC) Chr 13:
29.93 - 30.09 Mb
PubMed search [1] [2]

High-mobility group box 1, also known as HMGB1 and Amphoterin, is a human gene and protein that belongs to high mobility group.



HMGB1 has been shown to interact with P53.[1][2]


  1. ^ Imamura, T; Izumi H, Nagatani G, Ise T, Nomoto M, Iwamoto Y, Kohno K (Mar. 2001). "Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein". J. Biol. Chem. (United States) 276 (10): 7534–40. doi:10.1074/jbc.M008143200. ISSN 0021-9258. PMID 11106654.  
  2. ^ Dintilhac, Agnès; Bernués Jordi (Mar. 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. (United States) 277 (9): 7021–8. doi:10.1074/jbc.M108417200. ISSN 0021-9258. PMID 11748221.  

Further reading

  • Thomas JO, Travers AA (2001). "HMG1 and 2, and related 'architectural' DNA-binding proteins.". Trends Biochem. Sci. 26 (3): 167–74. doi:10.1016/S0968-0004(01)01801-1. PMID 11246022.  
  • Andersson U, Erlandsson-Harris H, Yang H, Tracey KJ (2003). "HMGB1 as a DNA-binding cytokine.". J. Leukoc. Biol. 72 (6): 1084–91. PMID 12488489.  
  • Erlandsson Harris H, Andersson U (2004). "Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator.". Eur. J. Immunol. 34 (6): 1503–12. doi:10.1002/eji.200424916. PMID 15162419.  
  • Jiang W, Pisetsky DS (2007). "Mechanisms of Disease: the role of high-mobility group protein 1 in the pathogenesis of inflammatory arthritis.". Nature clinical practice. Rheumatology 3 (1): 52–8. doi:10.1038/ncprheum0379. PMID 17203009.  
  • Ellerman JE, Brown CK, de Vera M, et al. (2007). "Masquerader: high mobility group box-1 and cancer.". Clin. Cancer Res. 13 (10): 2836–48. doi:10.1158/1078-0432.CCR-06-1953. PMID 17504981.  
  • Fossati S, Chiarugi A (2007). "Relevance of high-mobility group protein box 1 to neurodegeneration.". Int. Rev. Neurobiol. 82: 137–48. doi:10.1016/S0074-7742(07)82007-1. PMID 17678959.  
  • Parkkinen J, Rauvala H (1991). "Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin.". J. Biol. Chem. 266 (25): 16730–5. PMID 1909331.  
  • Wen L, Huang JK, Johnson BH, Reeck GR (1989). "A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.". Nucleic Acids Res. 17 (3): 1197–214. doi:10.1093/nar/17.3.1197. PMID 2922262.  
  • Bernués J, Espel E, Querol E (1986). "Identification of the core-histone-binding domains of HMG1 and HMG2.". Biochim. Biophys. Acta 866 (4): 242–51. PMID 3697355.  
  • Ge H, Roeder RG (1994). "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.". J. Biol. Chem. 269 (25): 17136–40. PMID 8006019.  
  • Parkkinen J, Raulo E, Merenmies J, et al. (1993). "Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.". J. Biol. Chem. 268 (26): 19726–38. PMID 8366113.  
  • Ferrari S, Finelli P, Rocchi M, Bianchi ME (1996). "The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.". Genomics 35 (2): 367–71. doi:10.1006/geno.1996.0369. PMID 8661151.  
  • Zappavigna V, Falciola L, Helmer-Citterich M, et al. (1996). "HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation.". Embo J. 15 (18): 4981–91. PMID 8890171.  
  • Xiang YY, Wang DY, Tanaka M, et al. (1997). "Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.". Int. J. Cancer 74 (1): 1–6. doi:10.1002/(SICI)1097-0215(19970220)74:1<1::AID-IJC1>3.0.CO;2-6. PMID 9036861.  
  • Rasmussen RK, Ji H, Eddes JS, et al. (1997). "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.". Electrophoresis 18 (3-4): 588–98. doi:10.1002/elps.1150180342. PMID 9150946.  
  • Jayaraman L, Moorthy NC, Murthy KG, et al. (1998). "High mobility group protein-1 (HMG-1) is a unique activator of p53.". Genes Dev. 12 (4): 462–72. doi:10.1101/gad.12.4.462. PMID 9472015.  
  • Milev P, Chiba A, Häring M, et al. (1998). "High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule.". J. Biol. Chem. 273 (12): 6998–7005. doi:10.1074/jbc.273.12.6998. PMID 9507007.  
  • Nagaki S, Yamamoto M, Yumoto Y, et al. (1998). "Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.". Biochem. Biophys. Res. Commun. 246 (1): 137–41. doi:10.1006/bbrc.1998.8589. PMID 9600082.  
  • Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy.". Genomics 50 (1): 44–52. doi:10.1006/geno.1998.5308. PMID 9628821.  
  • Boonyaratanakornkit V, Melvin V, Prendergast P, et al. (1998). "High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.". Mol. Cell. Biol. 18 (8): 4471–87. PMID 9671457.  

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