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High-mobility group box 2

PDB rendering based on 1ckt.
Available structures
1ckt, 1j3c, 1j3d, 1j3x
Identifiers
Symbols HMGB2; HMG2
External IDs OMIM163906 MGI96157 HomoloGene37582 GeneCards: HMGB2 Gene
RNA expression pattern
PBB GE HMGB2 208808 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3148 97165
Ensembl ENSG00000164104 n/a
UniProt P26583 n/a
RefSeq (mRNA) NM_002129 XM_001052174
RefSeq (protein) NP_002120 XP_001052174
Location (UCSC) Chr 4:
174.49 - 174.49 Mb
n/a
PubMed search [1] [2]

High mobility group protein B2 is a protein that in humans is encoded by the HMGB2 gene.[1][2]

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[2]

References

  1. ^ Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Jan 1992). "Sequence of human HMG2 cDNA". Nucleic Acids Res 19 (23): 6643. PMID 1754403.  
  2. ^ a b "Entrez Gene: HMGB2 high-mobility group box 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3148.  

Further reading

  • Alexandre S, Li WW, Lee AS (1993). "A human HMG2 cDNA with a novel 3'-untranslated region.". Nucleic Acids Res. 20 (23): 6413. doi:10.1093/nar/20.23.6413. PMID 1475204.  
  • Shirakawa H, Yoshida M (1992). "Structure of a gene coding for human HMG2 protein.". J. Biol. Chem. 267 (10): 6641–5. PMID 1551873.  
  • Bernués J, Espel E, Querol E (1986). "Identification of the core-histone-binding domains of HMG1 and HMG2.". Biochim. Biophys. Acta 866 (4): 242–51. PMID 3697355.  
  • Zwilling S, König H, Wirth T (1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.". Embo J. 14 (6): 1198–208. PMID 7720710.  
  • Shykind BM, Kim J, Sharp PA (1995). "Activation of the TFIID-TFIIA complex with HMG-2.". Genes Dev. 9 (11): 1354–65. doi:10.1101/gad.9.11.1354. PMID 7797075.  
  • Paull TT, Haykinson MJ, Johnson RC (1993). "The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.". Genes Dev. 7 (8): 1521–34. doi:10.1101/gad.7.8.1521. PMID 8339930.  
  • Wanschura S, Schoenmakers EF, Huysmans C, et al. (1997). "Mapping of the human HMG2 gene to 4q31.". Genomics 31 (2): 264–5. doi:10.1006/geno.1996.0046. PMID 8824816.  
  • Nagaki S, Yamamoto M, Yumoto Y, et al. (1998). "Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.". Biochem. Biophys. Res. Commun. 246 (1): 137–41. doi:10.1006/bbrc.1998.8589. PMID 9600082.  
  • Boonyaratanakornkit V, Melvin V, Prendergast P, et al. (1998). "High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.". Mol. Cell. Biol. 18 (8): 4471–87. PMID 9671457.  
  • Yumoto Y, Shirakawa H, Yoshida M, et al. (1998). "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro.". J. Biochem. 124 (3): 519–27. PMID 9722660.  
  • Aidinis V, Bonaldi T, Beltrame M, et al. (2000). "The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.". Mol. Cell. Biol. 19 (10): 6532–42. PMID 10490593.  
  • Butteroni C, De Felici M, Schöler HR, Pesce M (2001). "Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins.". J. Mol. Biol. 304 (4): 529–40. doi:10.1006/jmbi.2000.4238. PMID 11099378.  
  • Stros M, Ozaki T, Bacikova A, et al. (2002). "HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.". J. Biol. Chem. 277 (9): 7157–64. doi:10.1074/jbc.M110233200. PMID 11748232.  
  • Fan Z, Beresford PJ, Zhang D, Lieberman J (2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. PMID 11909973.  
  • Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners.". FEBS Lett. 517 (1-3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fan Z, Beresford PJ, Zhang D, et al. (2003). "Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.". Nat. Immunol. 4 (2): 145–53. doi:10.1038/ni885. PMID 12524539.  
  • Lv X, Xu DD, Liu DP, et al. (2003). "High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster.". Biochem. Cell Biol. 80 (6): 765–70. doi:10.1139/o02-164. PMID 12555809.  
  • Pallier C, Scaffidi P, Chopineau-Proust S, et al. (2004). "Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes.". Mol. Biol. Cell 14 (8): 3414–26. doi:10.1091/mbc.E02-09-0581. PMID 12925773.  

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