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Homeodomain-only protein

PDB rendering based on 2hi3.
Available structures
Symbols HOP; Cameo; LAGY; MGC20820; NECC1; OB1; SMAP31; Toto
External IDs OMIM607275 MGI1916782 HomoloGene15859 GeneCards: HOP Gene
RNA expression pattern
PBB GE HOP 211597 s at tn.png
More reference expression data
Species Human Mouse
Entrez 84525 74318
Ensembl ENSG00000171476 ENSMUSG00000059325
UniProt Q9BPY8 Q8R1H0
RefSeq (mRNA) NM_032495 NM_175606
RefSeq (protein) NP_115884 NP_783199
Location (UCSC) Chr 4:
57.21 - 57.24 Mb
Chr 5:
78.16 - 78.19 Mb
PubMed search [1] [2]

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.[1][2]

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[2]


  1. ^ Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA (Sep 2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell 110 (6): 713-23. PMID 12297045.  
  2. ^ a b "Entrez Gene: HOP homeodomain-only protein".  

Further reading

  • Kook H, Epstein JA (2004). "Hopping to the beat. Hop regulation of cardiac gene expression.". Trends Cardiovasc. Med. 13 (7): 261–4. doi:10.1016/S1050-1738(03)00107-5. PMID 14522464.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Asanoma K, Matsuda T, Kondo H, et al. (2003). "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif.". Genomics 81 (1): 15–25. doi:10.1016/S0888-7543(02)00011-3. PMID 12573257.  
  • Chen Y, Petersen S, Pacyna-Gengelbach M, et al. (2003). "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer.". Oncology 64 (4): 450–8. doi:10.1159/000070306. PMID 12759545.  
  • Kook H, Lepore JJ, Gitler AD, et al. (2003). "Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop.". J. Clin. Invest. 112 (6): 863–71. doi:10.1172/JCI200319137. PMID 12975471.  
  • Adu J, Leong FT, Smith NR, et al.. "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development.". Mech. Dev. 119 Suppl 1: S43–7. PMID 14516659.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Lemaire F, Millon R, Muller D, et al. (2004). "Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma.". Br. J. Cancer 91 (2): 258–61. doi:10.1038/sj.bjc.6601952. PMID 15213722.  
  • Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C (2005). "A novel homeobox gene overexpressed in thyroid carcinoma.". Thyroid 14 (7): 500–5. doi:10.1089/1050725041517020. PMID 15307938.  
  • Toruner GA, Ulger C, Alkan M, et al. (2004). "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma.". Cancer Genet. Cytogenet. 154 (1): 27–35. doi:10.1016/j.cancergencyto.2004.01.026. PMID 15381369.  
  • Asanoma K, Kato H, Inoue T, et al. (2004). "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts.". The Journal of reproductive medicine 49 (8): 617–26. PMID 15457851.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  
  • Kook H, Yung WW, Simpson RJ, et al. (2006). "Analysis of the structure and function of the transcriptional coregulator HOP.". Biochemistry 45 (35): 10584–90. doi:10.1021/bi060641s. PMID 16939210.  
  • Kee HJ, Kim JR, Nam KI, et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.  
  • Americo TA, Chiarini LB, Linden R (2007). "Signaling induced by hop/STI-1 depends on endocytosis.". Biochem. Biophys. Res. Commun. 358 (2): 620–5. doi:10.1016/j.bbrc.2007.04.202. PMID 17498662.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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