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Homeobox A11
Symbols HOXA11; HOX1; HOX1I
External IDs OMIM142958 MGI96172 HomoloGene4033 GeneCards: HOXA11 Gene
RNA expression pattern
PBB GE HOXA11 208493 at tn.png
PBB GE HOXA11 213823 at tn.png
More reference expression data
Species Human Mouse
Entrez 3207 15396
Ensembl ENSG00000005073 ENSMUSG00000038210
UniProt P31270 P31311
RefSeq (mRNA) NM_005523 NM_010450
RefSeq (protein) NP_005514 NP_034580
Location (UCSC) Chr 7:
27.19 - 27.19 Mb
Chr 6:
52.17 - 52.18 Mb
PubMed search [1] [2]

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXA11 homeobox A11".  

Further reading

  • Daftary GS, Taylor HS (2001). "Implantation in the human: the role of HOX genes.". Semin. Reprod. Med. 18 (3): 311–20. doi:10.1055/s-2000-12568. PMID 11299969.  
  • Daftary GS, Taylor HS (2001). "Molecular markers of implantation: clinical implications.". Curr. Opin. Obstet. Gynecol. 13 (3): 269–74. doi:10.1097/00001703-200106000-00004. PMID 11396649.  
  • Davies JA, Fisher CE (2002). "Genes and proteins in renal development.". Exp. Nephrol. 10 (2): 102–13. doi:10.1159/000049905. PMID 11937757.  
  • Eun Kwon H, Taylor HS (2005). "The role of HOX genes in human implantation.". Ann. N. Y. Acad. Sci. 1034: 1–18. doi:10.1196/annals.1335.001. PMID 15731295.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Miano JM, Firulli AB, Olson EN, et al. (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–5. doi:10.1073/pnas.93.2.900. PMID 8570656.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Potter SS, Branford WW (1998). "Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts.". Mamm. Genome 9 (10): 799–806. doi:10.1007/s003359900870. PMID 9745033.  
  • Taylor HS, Igarashi P, Olive DL, Arici A (1999). "Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium.". J. Clin. Endocrinol. Metab. 84 (3): 1129–35. doi:10.1210/jc.84.3.1129. PMID 10084606.  
  • Thompson AA, Nguyen LT (2001). "Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation.". Nat. Genet. 26 (4): 397–8. doi:10.1038/82511. PMID 11101832.  
  • Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity.". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.  
  • Fujino T, Suzuki A, Ito Y, et al. (2002). "Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15).". Blood 99 (4): 1428–33. doi:10.1182/blood.V99.4.1428. PMID 11830496.  
  • Fleischman RA, Letestu R, Mi X, et al. (2002). "Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome.". Br. J. Haematol. 116 (2): 367–75. doi:10.1046/j.1365-2141.2002.03263.x. PMID 11841440.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Chau YM, Pando S, Taylor HS (2002). "HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium.". J. Clin. Endocrinol. Metab. 87 (6): 2674–80. doi:10.1210/jc.87.6.2674. PMID 12050232.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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