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Homeobox A3
Identifiers
Symbols HOXA3; HOX1; HOX1E; MGC10155
External IDs OMIM142954 MGI96175 HomoloGene40725 GeneCards: HOXA3 Gene
RNA expression pattern
PBB GE HOXA3 208604 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3200 15400
Ensembl ENSG00000105997 ENSMUSG00000059723
UniProt O43365 P02831
RefSeq (mRNA) NM_030661 NM_010452
RefSeq (protein) NP_109377 NP_034582
Location (UCSC) Chr 7:
27.11 - 27.13 Mb
Chr 6:
52.1 - 52.14 Mb
PubMed search [1] [2]

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[3]

Contents

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXA3 homeobox A3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3200.  

Further reading

  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Manley NR, Capecchi MR (1998). "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.". Dev. Biol. 195 (1): 1–15. doi:10.1006/dbio.1997.8827. PMID 9520319.  
  • "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.  
  • Mulder GB, Manley N, Maggio-Price L (1999). "Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1.". Teratology 58 (6): 263–75. doi:10.1002/(SICI)1096-9926(199812)58:6<263::AID-TERA8>3.0.CO;2-A. PMID 9894676.  
  • Manzanares M, Nardelli J, Gilardi-Hebenstreit P, et al. (2002). "Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain.". Embo J. 21 (3): 365–76. doi:10.1093/emboj/21.3.365. PMID 11823429.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.". Nat. Methods 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160.  
  • Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMID 16582099.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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