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Homeobox A6

PDB rendering based on 1ahd.
Available structures
1ahd, 1hom, 1san, 2hoa, 9ant
Identifiers
Symbols HOXA6; HOX1; HOX1.2; HOX1B
External IDs OMIM142951 MGI96178 HomoloGene7765 GeneCards: HOXA6 Gene
RNA expression pattern
PBB GE HOXA6 208557 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3203 15403
Ensembl ENSG00000106006 ENSMUSG00000043219
UniProt P31267 Q0VEU7
RefSeq (mRNA) NM_024014 NM_010454
RefSeq (protein) NP_076919 NP_034584
Location (UCSC) Chr 7:
27.15 - 27.15 Mb
Chr 6:
52.14 - 52.14 Mb
PubMed search [1] [2]

Homeobox protein Hox-A6 is a protein that in humans is encoded by the HOXA6 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[3]

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXA6 homeobox A6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3203.  

Further reading

  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Walters JR, Howard A, Rumble HE, et al. (1997). "Differences in expression of homeobox transcription factors in proximal and distal human small intestine.". Gastroenterology 113 (2): 472–7. doi:10.1053/gast.1997.v113.pm9247466. PMID 9247466.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
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