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Homeobox A7

PDB rendering based on 1ahd.
Available structures
1ahd, 1hom, 1san, 2hoa, 9ant
Symbols HOXA7; HOX1; ANTP; HOX1.1; HOX1A
External IDs OMIM142950 MGI96179 HomoloGene56001 GeneCards: HOXA7 Gene
RNA expression pattern
PBB GE HOXA7 206847 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3204 15404
Ensembl ENSG00000122592 ENSMUSG00000038236
UniProt P31268 Q8JZW2
RefSeq (mRNA) NM_006896 NM_010455
RefSeq (protein) NP_008827 NP_034585
Location (UCSC) Chr 7:
27.16 - 27.16 Mb
Chr 6:
52.14 - 52.15 Mb
PubMed search [1] [2]

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXA7 homeobox A7".  

Further reading

  • Balling R, Mutter G, Gruss P, Kessel M (1989). "Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice.". Cell 58 (2): 337–47. doi:10.1016/0092-8674(89)90848-9. PMID 2568891.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos.". Mol. Reprod. Dev. 41 (2): 127–32. doi:10.1002/mrd.1080410202. PMID 7654365.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Knoepfler PS, Calvo KR, Chen H, et al. (1998). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14553–8. doi:10.1073/pnas.94.26.14553. PMID 9405651.  
  • Min W, Woo HJ, Lee CS, et al. (1998). "307-bp fragment in HOXA7 upstream sequence is sufficient for anterior boundary formation.". DNA Cell Biol. 17 (3): 293–9. doi:10.1089/dna.1998.17.293. PMID 9539109.  
  • McIlhatton MA, Bremner P, McMullin MF, et al. (1998). "Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.". Biochim. Biophys. Acta 1442 (2-3): 329–33. PMID 9804983.  
  • "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Kim MH, Jin H, Seol EY, et al. (2000). "Sequence analysis and tissue specific expression of human HOXA7.". Mol. Biotechnol. 14 (1): 19–24. doi:10.1385/MB:14:1:19. PMID 10911612.  
  • La Celle PT, Polakowska RR (2001). "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation.". J. Biol. Chem. 276 (35): 32844–53. doi:10.1074/jbc.M104598200. PMID 11435435.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.  
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.  
  • Bertrand FE, Spengeman JD, Shah N, LeBien TW (2004). "B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression.". Leukemia 17 (12): 2454–9. doi:10.1038/sj.leu.2403178. PMID 14562113.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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