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Homeobox B2
Identifiers
Symbols HOXB2; HOX2; HOX2H; Hox-2.8; K8
External IDs OMIM142967 MGI96183 HomoloGene37584 GeneCards: HOXB2 Gene
RNA expression pattern
PBB GE HOXB2 205453 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3212 103889
Ensembl ENSG00000173917 ENSMUSG00000075588
UniProt P14652 Q61682
RefSeq (mRNA) NM_002145 XM_001052073
RefSeq (protein) NP_002136 XP_001052073
Location (UCSC) Chr 17:
43.98 - 43.98 Mb
Chr 11:
96.17 - 96.17 Mb
PubMed search [1] [2]

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[3]

Contents

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXB2 homeobox B2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212.  

Further reading

  • Lavelle D, Ducksworth J, Eves E, et al. (1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences.". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7318–22. doi:10.1073/pnas.88.16.7318. PMID 1871139.  
  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Kongsuwan K, Webb E, Housiaux P, Adams JM (1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.". Embo J. 7 (7): 2131–8. PMID 2901346.  
  • Vieille-Grosjean I, Huber P (1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells.". J. Biol. Chem. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.  
  • Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". Embo J. 13 (14): 3339–47. PMID 7913891.  
  • Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells.". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.  
  • Davenne M, Maconochie MK, Neun R, et al. (1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain.". Neuron 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.  
  • Case SS, Huber P, Lloyd JA (2000). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.". DNA Cell Biol. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.  
  • Golpon HA, Geraci MW, Moore MD, et al. (2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.". Am. J. Pathol. 158 (3): 955–66. PMID 11238043.  
  • Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity.". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.  
  • Liu X, Zhang X (2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells.". Chin. J. Traumatol. 5 (1): 12–5. PMID 11835749.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ivins S, Pemberton K, Guidez F, et al. (2003). "Regulation of Hoxb2 by APL-associated PLZF protein.". Oncogene 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Segara D, Biankin AV, Kench JG, et al. (2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia.". Clin. Cancer Res. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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