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Homeobox B2
Symbols HOXB2; HOX2; HOX2H; Hox-2.8; K8
External IDs OMIM142967 MGI96183 HomoloGene37584 GeneCards: HOXB2 Gene
RNA expression pattern
PBB GE HOXB2 205453 at tn.png
More reference expression data
Species Human Mouse
Entrez 3212 103889
Ensembl ENSG00000173917 ENSMUSG00000075588
UniProt P14652 Q61682
RefSeq (mRNA) NM_002145 XM_001052073
RefSeq (protein) NP_002136 XP_001052073
Location (UCSC) Chr 17:
43.98 - 43.98 Mb
Chr 11:
96.17 - 96.17 Mb
PubMed search [1] [2]

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXB2 homeobox B2".  

Further reading

  • Lavelle D, Ducksworth J, Eves E, et al. (1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences.". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7318–22. doi:10.1073/pnas.88.16.7318. PMID 1871139.  
  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Kongsuwan K, Webb E, Housiaux P, Adams JM (1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.". Embo J. 7 (7): 2131–8. PMID 2901346.  
  • Vieille-Grosjean I, Huber P (1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells.". J. Biol. Chem. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.  
  • Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". Embo J. 13 (14): 3339–47. PMID 7913891.  
  • Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells.". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.  
  • Davenne M, Maconochie MK, Neun R, et al. (1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain.". Neuron 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.  
  • Case SS, Huber P, Lloyd JA (2000). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.". DNA Cell Biol. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.  
  • Golpon HA, Geraci MW, Moore MD, et al. (2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.". Am. J. Pathol. 158 (3): 955–66. PMID 11238043.  
  • Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity.". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.  
  • Liu X, Zhang X (2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells.". Chin. J. Traumatol. 5 (1): 12–5. PMID 11835749.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ivins S, Pemberton K, Guidez F, et al. (2003). "Regulation of Hoxb2 by APL-associated PLZF protein.". Oncogene 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Segara D, Biankin AV, Kench JG, et al. (2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia.". Clin. Cancer Res. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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