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Homeobox B3
Symbols HOXB3; HOX2; HOX2G; Hox-2.7
External IDs OMIM142966 MGI96184 HomoloGene1617 GeneCards: HOXB3 Gene
RNA expression pattern
PBB GE HOXB3 208414 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3213 15410
Ensembl ENSG00000120093 ENSMUSG00000048763
UniProt P14651 P09026
RefSeq (mRNA) NM_002146 NM_001079869
RefSeq (protein) NP_002137 NP_001073338
Location (UCSC) Chr 17:
43.98 - 44.01 Mb
Chr 11:
96.16 - 96.16 Mb
PubMed search [1] [2]

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXB3 homeobox B3".  

Further reading

  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". Embo J. 13 (14): 3339–47. PMID 7913891.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Bingle CD, Gowan S (1996). "Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter.". Biochem. J. 319 ( Pt 3): 669–74. PMID 8920965.  
  • Sauvageau G, Thorsteinsdottir U, Hough MR, et al. (1997). "Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.". Immunity 6 (1): 13–22. doi:10.1016/S1074-7613(00)80238-1. PMID 9052833.  
  • Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells.". J. Biol. Chem. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.  
  • Viganò MA, Di Rocco G, Zappavigna V, Mavilio F (1998). "Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.". Mol. Cell. Biol. 18 (11): 6201–12. PMID 9774637.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Nakamura N, Yoshimi T, Miura T (2002). "Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3.". Cell Growth Differ. 13 (4): 195–203. PMID 11971819.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Pineault N, Abramovich C, Ohta H, Humphries RK (2004). "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.". Mol. Cell. Biol. 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMID 14966272.  
  • Roche J, Zeng C, Barón A, et al. (2004). "Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics.". Leukemia 18 (6): 1059–63. doi:10.1038/sj.leu.2403366. PMID 15085154.  
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  
  • Speleman F, Cauwelier B, Dastugue N, et al. (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.". Leukemia 19 (3): 358–66. doi:10.1038/sj.leu.2403657. PMID 15674412.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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