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Homeobox B4
Symbols HOXB4; HOX2; HOX-2.6; HOX2F
External IDs OMIM142965 MGI96185 HomoloGene32095 GeneCards: HOXB4 Gene
Species Human Mouse
Entrez 3214 15412
Ensembl ENSG00000182742 ENSMUSG00000038692
UniProt P17483 P10284
RefSeq (mRNA) NM_024015 NM_010459
RefSeq (protein) NP_076920 NP_034589
Location (UCSC) Chr 17:
44.01 - 44.01 Mb
Chr 11:
96.13 - 96.14 Mb
PubMed search [1] [2]

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXB4 homeobox B4".  

Further reading

  • Petrini M, Quaranta MT, Testa U, et al. (1992). "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes.". Blood 80 (1): 185–93. PMID 1351762.  
  • Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.  
  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Bodey B, Bodey B, Siegel SE, Kaiser HE (2000). "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment.". In Vivo 14 (3): 419–24. PMID 10904875.  
  • Giannola DM, Shlomchik WD, Jegathesan M, et al. (2000). "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2.". J. Exp. Med. 192 (10): 1479–90. doi:10.1084/jem.192.10.1479. PMID 11085749.  
  • Pan Q, Simpson RU (2001). "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression.". J. Endocrinol. 169 (1): 153–9. doi:10.1677/joe.0.1690153. PMID 11250656.  
  • Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity.". Mol. Cell. Biol. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930.  
  • Kömüves LG, Michael E, Arbeit JM, et al. (2002). "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation.". Dev. Dyn. 224 (1): 58–68. doi:10.1002/dvdy.10085. PMID 11984874.  
  • Buske C, Feuring-Buske M, Abramovich C, et al. (2002). "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells.". Blood 100 (3): 862–8. doi:10.1182/blood-2002-01-0220. PMID 12130496.  
  • Schiedlmeier B, Klump H, Will E, et al. (2003). "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation.". Blood 101 (5): 1759–68. doi:10.1182/blood-2002-03-0767. PMID 12406897.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Theokli C, Morsi El-Kadi AS, Morgan R (2004). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation.". Dev. Dyn. 227 (1): 48–55. doi:10.1002/dvdy.10287. PMID 12701098.  
  • Kömüves LG, Ma XK, Stelnicki E, et al. (2004). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development.". Dev. Dyn. 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847.  
  • Zhu J, Giannola DM, Zhang Y, et al. (2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.". Blood 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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