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HOXB7: Wikis


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Homeobox B7

PDB rendering based on 1ahd.
Available structures
1ahd, 1hom, 1san, 2hoa, 9ant
Symbols HOXB7; HOX2; HHO.C1; HOX2C; Hox-2.3
External IDs OMIM142962 MGI96188 HomoloGene55828 GeneCards: HOXB7 Gene
RNA expression pattern
PBB GE HOXB7 216973 s at tn.png
PBB GE HOXB7 204778 x at tn.png
PBB GE HOXB7 204779 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3217 15415
Ensembl ENSG00000120087 ENSMUSG00000038721
UniProt P09629 P09024
RefSeq (mRNA) NM_004502 NM_010460
RefSeq (protein) NP_004493 NP_034590
Location (UCSC) Chr 17:
44.04 - 44.04 Mb
Chr 11:
96.1 - 96.11 Mb
PubMed search [1] [2]

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[1][2]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[3]


See also


HOXB7 has been shown to interact with PBX1[4] and CREB binding protein.[5]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459.  
  3. ^ "Entrez Gene: HOXB7 homeobox B7".  
  4. ^ Chang, C P; Shen W F, Rozenfeld S, Lawrence H J, Largman C, Cleary M L (Mar. 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. (UNITED STATES) 9 (6): 663–74. ISSN 0890-9369. PMID 7729685.  
  5. ^ Chariot, A; van Lint C, Chapelier M, Gielen J, Merville M P, Bours V (Jul. 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene (ENGLAND) 18 (27): 4007–14. doi:10.1038/sj.onc.1202776. ISSN 0950-9232. PMID 10435624.  

Further reading

  • Baier LJ, Hannibal MC, Hanley EW, Nabel GJ (1991). "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain.". Blood 78 (4): 1047–55. PMID 1678287.  
  • Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.  
  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.  
  • Shen WF, Largman C, Lowney P, et al. (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–40. doi:10.1073/pnas.86.21.8536. PMID 2573064.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Simeone A, Mavilio F, Acampora D, et al. (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. doi:10.1073/pnas.84.14.4914. PMID 2885844.  
  • Lill MC, Fuller JF, Herzig R, et al. (1995). "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation.". Blood 85 (3): 692–7. PMID 7530503.  
  • Chang CP, Shen WF, Rozenfeld S, et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.  
  • Corsetti MT, Levi G, Lancia F, et al. (1995). "Nucleolar localisation of three Hox homeoproteins.". J. Cell. Sci. 108 ( Pt 1): 187–93. PMID 7738096.  
  • Inamori K, Takeshita K, Chiba S, et al. (1993). "Identification of homeobox genes expressed in human T-lymphocytes.". Biochem. Biophys. Res. Commun. 196 (1): 203–8. doi:10.1006/bbrc.1993.2235. PMID 8105782.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Miano JM, Firulli AB, Olson EN, et al. (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–5. doi:10.1073/pnas.93.2.900. PMID 8570656.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Caré A, Silvani A, Meccia E, et al. (1996). "HOXB7 constitutively activates basic fibroblast growth factor in melanomas.". Mol. Cell. Biol. 16 (9): 4842–51. PMID 8756643.  
  • LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains.". Oncogene 15 (17): 2059–67. doi:10.1038/sj.onc.1201367. PMID 9366523.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Stelnicki EJ, Kömüves LG, Kwong AO, et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.". J. Invest. Dermatol. 110 (2): 110–5. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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