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Homeobox B8
Identifiers
Symbols HOXB8; HOX2; HOX2D; Hox-2.4
External IDs OMIM142963 MGI96189 HomoloGene7768 GeneCards: HOXB8 Gene
RNA expression pattern
PBB GE HOXB8 221278 at tn.png
PBB GE HOXB8 204778 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3218 15416
Ensembl ENSG00000120068 ENSMUSG00000056648
UniProt P17481 P09632
RefSeq (mRNA) NM_024016 NM_010461
RefSeq (protein) NP_076921 NP_034591
Location (UCSC) Chr 17:
44.04 - 44.05 Mb
Chr 11:
96.1 - 96.1 Mb
PubMed search [1] [2]

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.[3]

Contents

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXB8 homeobox B8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218.  

Further reading

  • Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.  
  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Vider BZ, Zimber A, Hirsch D, et al. (1997). "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression.". Biochem. Biophys. Res. Commun. 232 (3): 742–8. doi:10.1006/bbrc.1997.6364. PMID 9126347.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.  
  • Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.". Oncogene 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.  
  • Greer JM, Capecchi MR (2002). "Hoxb8 is required for normal grooming behavior in mice.". Neuron 33 (1): 23–34. doi:10.1016/S0896-6273(01)00564-5. PMID 11779477.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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