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Homeobox C10
Symbols HOXC10; HOX3I; MGC5259
External IDs OMIM605560 MGI96192 HomoloGene9680 GeneCards: HOXC10 Gene
RNA expression pattern
PBB GE HOXC10 218959 at tn.png
More reference expression data
Species Human Mouse
Entrez 3226 209448
Ensembl ENSG00000180818 ENSMUSG00000022484
UniProt Q9NYD6 Q8BZY5
RefSeq (mRNA) NM_017409 NM_010462
RefSeq (protein) NP_059105 NP_034592
Location (UCSC) Chr 12:
52.67 - 52.67 Mb
Chr 15:
102.79 - 102.8 Mb
PubMed search [1] [2]

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.[1][2]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.[2]


  1. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  2. ^ a b "Entrez Gene: HOXC10 homeobox C10".  

Further reading

  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMID 2878432.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.". FEBS Lett. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.  
  • de Stanchina E, Gabellini D, Norio P, et al. (2000). "Selection of homeotic proteins for binding to a human DNA replication origin.". J. Mol. Biol. 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276.  
  • Sandrock B, Egly JM (2001). "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.". J. Biol. Chem. 276 (38): 35328–33. doi:10.1074/jbc.M105570200. PMID 11445587.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gabellini D, Colaluca IN, Vodermaier HC, et al. (2003). "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.". Embo J. 22 (14): 3715–24. doi:10.1093/emboj/cdg340. PMID 12853486.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Zhai Y, Kuick R, Nan B, et al. (2007). "Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion.". Cancer Res. 67 (21): 10163–72. doi:10.1158/0008-5472.CAN-07-2056. PMID 17974957.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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