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Homeobox C13
Symbols HOXC13; HOX3; HOX3G
External IDs OMIM142976 MGI99560 HomoloGene7770 GeneCards: HOXC13 Gene
RNA expression pattern
PBB GE HOXC13 219832 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3229 15422
Ensembl ENSG00000123364 ENSMUSG00000001655
UniProt P31276 P50207
RefSeq (mRNA) NM_017410 NM_010464
RefSeq (protein) NP_059106 NP_034594
Location (UCSC) Chr 12:
52.62 - 52.63 Mb
Chr 15:
102.75 - 102.76 Mb
PubMed search [1] [2]

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551-3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXC13 homeobox C13".  

Further reading

  • Godwin AR, Capecchi MR (2000). "Hair defects in Hoxc13 mutant mice.". J. Investig. Dermatol. Symp. Proc. 4 (3): 244–7. doi:10.1038/sj.jidsp.5640221. PMID 10674376.  
  • Panagopoulos I, Isaksson M, Billström R, et al. (2003). "Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).". Genes Chromosomes Cancer 36 (1): 107–12. doi:10.1002/gcc.10139. PMID 12461755.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMID 2878432.  
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.  
  • Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.". FEBS Lett. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.  
  • de Stanchina E, Gabellini D, Norio P, et al. (2000). "Selection of homeotic proteins for binding to a human DNA replication origin.". J. Mol. Biol. 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276.  
  • Kulessa H, Turk G, Hogan BL (2001). "Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle.". Embo J. 19 (24): 6664–74. doi:10.1093/emboj/19.24.6664. PMID 11118201.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Pruett ND, Tkatchenko TV, Jave-Suarez L, et al. (2005). "Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13.". J. Biol. Chem. 279 (49): 51524–33. doi:10.1074/jbc.M404331200. PMID 15385554.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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