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Homeobox D11
Symbols HOXD11; HOX4; HOX4F
External IDs OMIM142986 MGI96203 HomoloGene7368 GeneCards: HOXD11 Gene
RNA expression pattern
PBB GE HOXD11 214604 at tn.png
More reference expression data
Species Human Mouse
Entrez 3237 15431
Ensembl ENSG00000128713 ENSMUSG00000042499
UniProt P31277 P23813
RefSeq (mRNA) NM_021192 NM_008273
RefSeq (protein) NP_067015 NP_032299
Location (UCSC) Chr 2:
176.68 - 176.68 Mb
Chr 2:
74.48 - 74.49 Mb
PubMed search [1] [2]

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.[3] [4][5][6]


See also


  1. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.  
  2. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXD11 homeobox D11".  
  4. ^ Davis AP, Capecchi MR (1 August 1994). "Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11". Development 120 (8): 2187–98. PMID 7925020.  
  5. ^ Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR (June 1995). "Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11". Nature 375 (6534): 791–5. doi:10.1038/375791a0. PMID 7596412.  
  6. ^ Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development 122 (4): 1175–85. PMID 8620844.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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