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Homeobox D3
Symbols HOXD3; HOX1D; HOX4; HOX4A; Hox-4.1; MGC10470
External IDs OMIM142980 MGI96207 HomoloGene5034 GeneCards: HOXD3 Gene
RNA expression pattern
PBB GE HOXD3 206602 s at tn.png
PBB GE HOXD3 206601 s at tn.png
PBB GE HOXD3 217076 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3232 15434
Ensembl ENSG00000128652 n/a
UniProt P31249 n/a
RefSeq (mRNA) NM_006898 NM_010468
RefSeq (protein) NP_008829 NP_034598
Location (UCSC) Chr 2:
176.74 - 176.75 Mb
PubMed search [1] [2]

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[3]


See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146.  
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459.  
  3. ^ a b "Entrez Gene: HOXD3 homeobox D3".  

Further reading

  • Taniguchi Y, Fujii A, Moriuchi T (1992). "Cloning and sequencing of the human homeobox gene HOX4A.". Biochim. Biophys. Acta 1132 (3): 332–4. PMID 1358204.  
  • Magli MC, Barba P, Celetti A, et al. (1991). "Coordinate regulation of HOX genes in human hematopoietic cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6348–52. doi:10.1073/pnas.88.14.6348. PMID 1712489.  
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.  
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652.  
  • Cannizzaro LA, Croce CM, Griffin CA, et al. (1987). "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13.". Am. J. Hum. Genet. 41 (1): 1–15. PMID 2886047.  
  • Taniguchi Y, Komatsu N, Moriuchi T (1995). "Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties.". Blood 85 (10): 2786–94. PMID 7742539.  
  • Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". Embo J. 13 (14): 3339–47. PMID 7913891.  
  • Manley NR, Capecchi MR (1998). "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.". Dev. Biol. 195 (1): 1–15. doi:10.1006/dbio.1997.8827. PMID 9520319.  
  • Del Campo M, Jones MC, Veraksa AN, et al. (1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster.". Am. J. Hum. Genet. 65 (1): 104–10. doi:10.1086/302467. PMID 10364522.  
  • Myers C, Charboneau A, Boudreau N (2000). "Homeobox B3 promotes capillary morphogenesis and angiogenesis.". J. Cell Biol. 148 (2): 343–51. doi:10.1083/jcb.148.2.343. PMID 10648567.  
  • Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1.". Cytogenet. Cell Genet. 90 (1-2): 151–3. doi:10.1159/000015651. PMID 11060466.  
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.  
  • Okubo Y, Hamada J, Takahashi Y, et al. (2002). "Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities.". Clin. Exp. Metastasis 19 (6): 503–11. doi:10.1023/A:1020346211686. PMID 12405287.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Boudreau NJ, Varner JA (2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis.". J. Biol. Chem. 279 (6): 4862–8. doi:10.1074/jbc.M305190200. PMID 14610084.  
  • Hansen SL, Myers CA, Charboneau A, et al. (2004). "HoxD3 accelerates wound healing in diabetic mice.". Am. J. Pathol. 163 (6): 2421–31. PMID 14633614.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Chen Y, Xu B, Arderiu G, et al. (2004). "Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice.". J. Cereb. Blood Flow Metab. 24 (11): 1280–7. doi:10.1097/01.WCB.0000141770.09022.AB. PMID 15545924.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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