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Heat shock transcription factor 4
Symbols HSF4; CTM
External IDs OMIM602438 MGI1347058 HomoloGene31042 GeneCards: HSF4 Gene
RNA expression pattern
PBB GE HSF4 210977 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3299 26386
Ensembl ENSG00000102878 n/a
UniProt Q9ULV5 n/a
RefSeq (mRNA) NM_001040667 NM_011939
RefSeq (protein) NP_001035757 NP_036069
Location (UCSC) Chr 16:
65.76 - 65.76 Mb
PubMed search [1] [2]

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.[1][2][3][4]

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.[4]


See also


  1. ^ Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (Jan 1997). "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator". Mol Cell Biol 17 (1): 469-81. PMID 8972228.  
  2. ^ Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A (Nov 1999). "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing". J Biol Chem 274 (39): 27845-56. PMID 10488131.  
  3. ^ Bu L, Jin Y, Shi Y, Chu R, Ban A, Eiberg H, Andres L, Jiang H, Zheng G, Qian M, Cui B, Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X (Jun 2002). "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract". Nat Genet 31 (3): 276-8. doi:10.1038/ng921. PMID 12089525.  
  4. ^ a b "Entrez Gene: HSF4 heat shock transcription factor 4".  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Smaoui N, Beltaief O, BenHamed S, et al. (2004). "A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract.". Invest. Ophthalmol. Vis. Sci. 45 (8): 2716–21. doi:10.1167/iovs.03-1370. PMID 15277496.  
  • Somasundaram T, Bhat SP (2004). "Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter.". J. Biol. Chem. 279 (43): 44497–503. doi:10.1074/jbc.M405813200. PMID 15308659.  
  • Forshew T, Johnson CA, Khaliq S, et al. (2005). "Locus heterogeneity in autosomal recessive congenital cataracts: linkage to 9q and germline HSF4 mutations.". Hum. Genet. 117 (5): 452–9. doi:10.1007/s00439-005-1309-9. PMID 15959809.  
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Tu N, Hu Y, Mivechi NF (2006). "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins.". J. Cell. Biochem. 98 (6): 1528–42. doi:10.1002/jcb.20865. PMID 16552721.  
  • Ke T, Wang QK, Ji B, et al. (2006). "Novel HSF4 mutation causes congenital total white cataract in a Chinese family.". Am. J. Ophthalmol. 142 (2): 298–303. doi:10.1016/j.ajo.2006.03.056. PMID 16876512.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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