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HT-0712: Wikis


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Systematic (IUPAC) name
CAS number 617720-02-2
ATC code  ?
PubChem  ?
Chemical data
Formula C 25H31NO3  
Mol. mass 393.53 g/mol
Synonyms HT-0712, IPL 455,903
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

HT-0712 is an experimental cognitive enhancing drug (nootropic) which is currently undergoing clinical trials. It is currently being licensed by Helicon Therapeutics in Cleveland, Ohio. It was originally discovered and tested as part of a preclinical anti-inflammatory program by Inflazyme Pharmaceuticals.


Mechanism of action

HT-0712 appears to act as a PDE4-inhibitor, thereby increasing cAMP levels. When cAMP levels are increased in neurons, this may trigger activation of cAMP response element-binding proteins (CREB). CREBs are transcription factors involved in the formation of long-term memory.

The side effects of the drug are not yet fully known.

Medical use

Middle-aged people, seniors, and possibly those suffering from dementia, who have a hard time remembering everyday events, can possibly benefit from this drug.

Performance enhancing use

Many students may be inclined to use nootropics for school and college life for exams and finals. This could also be an effective alternative or adjunctive to the use of caffeine as a study aid.


United States Patent 20040224316

External links



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