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5-hydroxytryptamine (serotonin) receptor 3B
Symbol HTR3B
External IDs OMIM604654 MGI1861899 HomoloGene38131 IUPHAR: 5-HT3B GeneCards: HTR3B Gene
Species Human Mouse
Entrez 9177 57014
Ensembl ENSG00000149305 ENSMUSG00000008590
UniProt O95264 Q9JHJ5
RefSeq (mRNA) NM_006028 NM_020274
RefSeq (protein) NP_006019 NP_064670
Location (UCSC) Chr 11:
113.28 - 113.32 Mb
Chr 9:
48.74 - 48.77 Mb
PubMed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.[1][2]


  1. ^ Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature 397 (6717): 359–63. doi:10.1038/16941. PMID 9950429.  
  2. ^ Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–810. doi:10.1074/jbc.274.43.30799. PMID 10521471.  

Further reading

  • Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.". Eur. J. Hum. Genet. 17 (7): 946-57. doi:10.1038/ejhg.2008.264. PMID 19156168.  
  • Meineke C, Tzvetkov MV, Bokelmann K, et al. (2008). "Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene.". Pharmacogenet. Genomics 18 (3): 219-30. doi:10.1097/FPC.0b013e3282f51092. PMID 18300944.  
  • Levran O, Londono D, O'Hara K, et al. (2008). "Genetic susceptibility to heroin addiction: a candidate gene association study.". Genes, Brain and Behavior 7 (7): 720-9. doi:10.1111/j.1601-183X.2008.00410.x. PMID 18518925.  
  • Kato M, Fukuda T, Wakeno M, et al. (2006). "Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients.". Neuropsychobiology 53 (4): 186-95. doi:10.1159/000094727. PMID 16874005.  
  • Hu XQ, Peoples RW (2008). "The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor.". J. Biol. Chem. 283 (11): 6826-31. doi:10.1074/jbc.M707571200. PMID 18187416.  
  • Krzywkowski K, Davies PA, Feinberg-Zadek PL, et al. (2008). "High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.". Proc. Natl. Acad. Sci. U.S.A. 105 (2): 722-7. doi:10.1073/pnas.0708454105. PMID 18184810.  
  • Ji X, Takahashi N, Branko A, et al. (2008). "An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.". Nagoya journal of medical science 70 (1-2): 11-7. PMID 18807291.  
  • Kato M, Serretti A (2008). "Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.". Mol. Psychiatry: HASH(0x155b370). doi:10.1038/mp.2008.116. PMID 18982004.  
  • Walstab J, Hammer C, Bönisch H, et al. (2008). "Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors.". Pharmacogenet. Genomics 18 (9): 793-802. doi:10.1097/FPC.0b013e3283050117. PMID 18698232.  
  • Yosifova A, Mushiroda T, Stoianov D, et al. (2009). "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.". Journal of affective disorders 117 (1-2): 87-97. doi:10.1016/j.jad.2008.12.021. PMID 19328558.  
  • Tzvetkov MV, Meineke C, Oetjen E, et al. (2007). "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine.". Gene 386 (1-2): 52-62. doi:10.1016/j.gene.2006.08.002. PMID 17010535.  
  • Oades RD, Lasky-Su J, Christiansen H, et al. (2008). "The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.". Behavioral and brain functions : BBF 4: 48. doi:10.1186/1744-9081-4-48. PMID 18937842.  
  • Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.". J. Cancer Res. Clin. Oncol. 134 (10): 1079-86. doi:10.1007/s00432-008-0387-1. PMID 18389280.  
  • Tanaka M, Kobayashi D, Murakami Y, et al. (2008). "Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea.". Int. J. Neuropsychopharmacol. 11 (2): 261-7. doi:10.1017/S1461145707007985. PMID 17697394.  
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808-16. doi:10.1002/ajmg.b.30902. PMID 19086053.  
  • Krzywkowski K, Davies PA, Irving AJ, et al. (2008). "Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.". Pharmacogenet. Genomics 18 (12): 1027-40. doi:10.1097/FPC.0b013e328310f950. PMID 19008750.  
  • Smith AK, Dimulescu I, Falkenberg VR, et al. (2008). "Genetic evaluation of the serotonergic system in chronic fatigue syndrome.". Psychoneuroendocrinology 33 (2): 188-97. doi:10.1016/j.psyneuen.2007.11.001. PMID 18079067.  
  • de Krom M, Staal WG, Ophoff RA, et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder.". Biol. Psychiatry 65 (7): 625-30. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789.  
  • Ducci F, Enoch MA, Yuan Q, et al. (2009). "HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors.". Alcohol 43 (1): 73-84. doi:10.1016/j.alcohol.2008.09.005. PMID 19185213.  

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