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5-hydroxytryptamine (serotonin) receptor 3, family member C
Symbol HTR3C
External IDs OMIM610121 HomoloGene50847 IUPHAR: 5-HT3C GeneCards: HTR3C Gene
Species Human Mouse
Entrez 170572 n/a
Ensembl ENSG00000178084 n/a
UniProt n/a n/a
RefSeq (mRNA) NM_130770 n/a
RefSeq (protein) NP_570126 n/a
Location (UCSC) Chr 3:
185.25 - 185.26 Mb
PubMed search [1] n/a

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene.[1][2][1] The protein encoded by this gene is a subunit of the 5-HT3 receptor.[2]


  1. ^ a b Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene 310: 101-11. PMID 12801637.  
  2. ^ a b Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans 32 (Pt3): 547-52. doi:10.1042/BST0320547. PMID 15157181.  

Further reading

  • Karnovsky AM, Gotow LF, McKinley DD, et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3.". Gene 319: 137-48. PMID 14597179.  
  • Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.". J. Cancer Res. Clin. Oncol. 134 (10): 1079-86. doi:10.1007/s00432-008-0387-1. PMID 18389280.  
  • Ward MB, Kotasek D, McKinnon RA (2008). "Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy.". Pharmacogenomics 9 (8): 1027-33. doi:10.2217/14622416.9.8.1027. PMID 18681779.  

External links



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