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HZ-2: Wikis


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Systematic (IUPAC) name
Dimethyl 3,7-dimethyl-9-oxo-2,4-dipyridin-2-yl-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate
CAS number 253304-60-8
ATC code  ?
PubChem 356604
Chemical data
Formula C 23H26N4O5  
Mol. mass 438.475 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

HZ-2 is a drug which acts as a highly selective κ-opioid agonist.[1] It is a potent analgesic with around the same potency as morphine, with a long duration of action and high oral bioavailability.[2][3] Side effects include sedation, nausea and dysphoria as well as diuretic effects.[4]


  1. ^ Siener T, Cambareri A, Kuhl U, Englberger W, Haurand M, Kögel B, Holzgrabe U. Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones. Journal of Medicinal Chemistry. 2000 Oct 5;43(20):3746-51. PMID 11020289
  2. ^ Holzgrabe U, Cambareri A, Kuhl U, Siener T, Brandt W, Strassburger W, Friderichs E, Englberger W, Kögel B, Haurand M. Diazabicyclononanones, a potent class of kappa opioid analgesics. Farmaco. 2002 Jul;57(7):531-4. PMID 12164207
  3. ^ Holzgrabe U, Brandt W. Mechanism of action of the diazabicyclononanone-type kappa-agonists. Journal of Medicinal Chemistry. 2003 Apr 10;46(8):1383-9. PMID 12672238
  4. ^ Kögel B, Christoph T, Friderichs E, Hennies HH, Matthiesen T, Schneider J, Holzgrabe U. HZ2, a Selective Kappa-Opioid Agonist. CNS Drug Reviews. 1998; 4(1):54-70.


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