The Full Wiki

More info on Halazepam

Halazepam: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Halazepam
Systematic (IUPAC) name
7-chloro- 5-phenyl- 1-(2,2,2-trifluoroethyl) -1,3-dihydro- 2H-1,4-benzodiazepin- 2-one
Identifiers
CAS number 23092-17-3
ATC code N05BA13
PubChem 31640
DrugBank APRD01009
Chemical data
Formula C 17H12ClF3N2O 
Mol. mass 352.7
Synonyms 9-chloro- 6-phenyl- 2-(2,2,2-trifluoroethyl)- 2,5-diazabicyclo[5.4.0] undeca- 5,8,10,12-tetraen -3-one
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status Schedule IV (US)
Routes Oral
 Yes check.svgY(what is this?)  (verify)

Halazepam is a benzodiazepine derivative and is marketed under the brand names Alapryl and Pacinone. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoroethyl derivative of nordazepam.[1] While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.[2] Halazepam has active benzodiazepine metabolites.[3]

Contents

Indications

Halazepam is indicated for the treatment of anxiety.[4]

See also

References

  1. ^ Greenblatt, D. J.; A. Locniskar and R. I. Shader (June 12, 1982). "Halazepam, another precursor of desmethyldiazepam". Lancet 1 (8285): 1358–9. PMID 6123659.  
  2. ^ Fann, W. E.; W. M. Pitts and J. C. Wheless (Mar-Apr 1982). "Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine". Pharmacotherapy 2 (2): 72–9. PMID 6152591.  
  3. ^ Jochemsen R, Breimer DD (1984). "Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles". Curr Med Res Opin 8 Suppl 4: 60–79. PMID 6144464.  
  4. ^ Lozano, Lozano, Lozano, et al. (1990). "[Open clinical study of the efficacy and safety of Halazepam in anxiety disorders]" (in Spanish; Castilian). Actas Luso Esp Neurol Psiquiatr Cienc Afines 18 (4): 205–11. PMID 1981637.  

External links








Got something to say? Make a comment.
Your name
Your email address
Message