| Hamilton O. Smith | |
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![]() Hamilton O. Smith
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| Born |
August 23, 1931 |
| Nationality | United States |
| Fields | microbiology |
| Known for | restriction enzymes |
| Notable awards | Nobel Prize in Physiology or Medicine in 1978 |
Hamilton Othanel Smith (born August 23, 1931) is an American microbiologist and Nobel laureate.
Smith was born on August 23, 1931, and graduated from University Laboratory High School of Urbana, Illinois. He attended the University of Illinois at Urbana-Champaign, but in 1950 transferred to the University of California, Berkeley, where he earned his B.A. in Mathematics in 1952 [1]. He received his medical degree from Johns Hopkins University in 1956.
He was awarded the Nobel Prize in Physiology or Medicine in 1978 for discovering type II restriction enzymes with Werner Arber and Daniel Nathans as co-recipients.
He later became a leading figure in the nascent field of genomics, when in 1995 he and a team at The Institute for Genomic Research sequenced the first bacterial genome, that of Haemophilus influenzae. H. influenza was the same organism in which Smith had discovered restriction enzymes in the late 1960s. He subsequently played a key role in the sequencing of many of the early genomes at The Institute for Genomic Research, and in the sequencing of the human genome at Celera Genomics, which he joined when it was founded in 1998.
More recently, he has directed a team at the J. Craig Venter Institute that works towards creating a synthetic bacterium, Mycoplasma laboratorium. In 2003 the same group synthetically assembled the genome of a virus, Phi X 174 bacteriophage. Currently, Smith is scientific director of pivately-held Synthetic Genomics, which was founded in 2005 by Craig Venter to continue this work. Currently, Synthetic Genomics is working to produce biofuels on an industrial-scale using recombinant algae and other microorganisms.[1]
Hamilton Othanel Smith (born August 23, 1931) is a microbiologist and a Nobel prize winner. He was given the 1978 Nobel Prize in Physiology or Medicine. He was the leader in the field of genomics.
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