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Hereditary motor and sensory neuropathy
Classification and external resources
eMedicine neuro/468
MeSH D015417

Hereditary motor and sensory neuropathies (HMSN) are a group of neuropathies which are characterized by their impact upon both afferent and efferent neural communication.

They are more common than hereditary sensory and autonomic neuropathies.[1]



In 1968, it was classified from groups I to VII: [2][3]

Type Name Diseases Database OMIM
I Charcot-Marie-Tooth disease 1 5815 118220, 118200
II Charcot-Marie-Tooth disease 2 2343 118210, 600882
III Dejerine Sottas syndrome 5821 145900
IV Refsum's disease 11213 266500
V HMSN+hereditary spastic paraplegia - 600361
VI HMSN+hereditary optic atrophy 32095 601152
VII HMSN+retinitis pigmentosa 32094 -

HMSN is sometimes equated with Charcot-Marie-Tooth disease.[4][5]

See also


  1. ^ Houlden H, Blake J, Reilly MM (October 2004). "Hereditary sensory neuropathies". Curr. Opin. Neurol. 17 (5): 569–77. doi:10.1097/00019052-200410000-00007. PMID 15367861.  
  2. ^ "eMedicine - Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies : Article by Aamir Hashmat".  
  3. ^ Dyck PJ, Lambert EH (June 1968). "Lower motor and primary sensory neuron diseases with peroneal muscular atrophy. I. Neurologic, genetic, and electrophysiologic findings in hereditary polyneuropathies". Arch. Neurol. 18 (6): 603–18. PMID 4297451.  
  4. ^ Horacek O, Mazanec R, Morris CE, Kobesova A (October 2007). "Spinal deformities in hereditary motor and sensory neuropathy: a retrospective qualitative, quantitative, genotypical, and familial analysis of 175 patients". Spine 32 (22): 2502–8. doi:10.1097/BRS.0b013e3181573d4e. PMID 18090092.  
  5. ^ Bertorini T, Narayanaswami P, Rashed H (November 2004). "Charcot-Marie-Tooth disease (hereditary motor sensory neuropathies) and hereditary sensory and autonomic neuropathies". Neurologist 10 (6): 327–37. doi:10.1097/01.nrl.0000145596.38640.27. PMID 15518599.  

Further reading



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