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Heterocodeine: Wikis

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Systematic (IUPAC) name
(5α,6α)-6-methoxy- 17-methyl- 7,8-didehydro- 4,5-epoxymorphinan- 3-ol
CAS number 639-47-4
ATC code none
PubChem 5462505
Chemical data
Formula C 18H21NO3  
Mol. mass 299.364 g/mol
Synonyms Heterocodeine, Morphine 6-methyl ether
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status  ? (US)
Routes  ?

Heterocodeine (6-methylmorphine) is an opiate derivative, the 6-methyl ether of morphine, and a structural isomer of codeine. Heterocodeine was first synthesised in 1932,[1] and can be made from morphine by selective methylation.[2]

Heterocodeine is 6 times more potent than morphine[3] due to having a substitution at the 6-hydroxy position, in a similar manner to 6-acetylmorphine.[4] The drug methyldihydromorphine (dihydroheterocodeine) is a derivative of heterocodeine.


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