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Histamine N-methyltransferase: Wikis

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histamine N-methyltransferase
Histamine n-methyltransferase1.png
Crystallographic structure of human histamine N-methyltransferase
Identifiers
EC number 2.1.1.8
CAS number 9029-80-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures
Gene Ontology AmiGO / EGO
histamine N-methyltransferase
Identifiers
Symbol HNMT
Entrez 3176
HUGO 5028
OMIM 605238
RefSeq NM_006895
UniProt P50135
Other data
Locus Chr. 2 q22.1

Histamine N-methyltransferase (HMT, HNMT) is one of two enzymes involved in the metabolism of histamine. The other being diamine oxidase. Histamine N-methyltransferase catalyzes the methylation of histamine in the presence of S-adenosylmethionine (SAM) forming N-methylhistamine. HMT is present in most body tissues but is not present in fluid. Histamine N-methyltransferase is encoded by a single gene which has been mapped to chromosome 2.

References

  • Brown DD, Tomchick R, Axelrod J (November 1959). "The distribution and properties of a histamine-methylating enzyme". J. Biol. Chem. 234: 2948–50. PMID 13804910.  

External links

PDB [1] Horton, J.R., Sawada, K., Nishibori, M., Zhang, X., Cheng, X. (August 2002) "Crystal Structure Analysis of Human Histamine Methyltransferase (Thr105 Polymorphic Variant) Complexed with AdoHcy and Histamine"

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