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Histamine trifluoromethyl toluidide
Histamine trifluoromethyl toluidide.png
IUPAC name
Other names HTMT
CAS number 103827-16-3
PubChem 124846
Molecular formula C19H25F3N4O
Molar mass 382.42321
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Histamine trifluoromethyl toluidide (HTMT) is a mixed H1/H2 histamine agonist which is significantly more potent than histamine itself.[1] It also produces additional actions which appear to be independent of histamine receptors.[2][3]


  1. ^ Whyment AD, Blanks AM, Lee K, Renaud LP, Spanswick D. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. Journal of Neurophysiology. 2006 Apr;95(4):2492-500. PMID 16354729
  2. ^ Qiu R, Melmon KL, Khan MM. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of Pharmacology and Experimental Therapeutics. 1990 Jun;253(3):1245-52. PMID 2359026
  3. ^ Kim DC, Lee SY, Jun DJ, Kim SH, Lee JH, Hur EM, Baek NI, Kim KT. Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors. Biochemical Pharmacology. 2005 Nov 25;70(11):1613-22. PMID 16219299


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