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Host cell factor C1 (VP16-accessory protein)
Identifiers
Symbols HCFC1; CFF; HCF-1; HCF1; HFC1; MGC70925; VCAF
External IDs OMIM300019 MGI105942 HomoloGene3898 GeneCards: HCFC1 Gene
RNA expression pattern
PBB GE HCFC1 202474 s at tn.png
PBB GE HCFC1 202473 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3054 15161
Ensembl ENSG00000172534 ENSMUSG00000031386
UniProt P51610 Q3USQ6
RefSeq (mRNA) NM_005334 NM_008224
RefSeq (protein) NP_005325 NP_032250
Location (UCSC) Chr X:
152.87 - 152.89 Mb
Chr X:
70.2 - 70.22 Mb
PubMed search [1] [2]

Host cell factor is a protein that in humans is encoded by the HCFC1 gene.[1][2]

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[2]

Interactions

Host cell factor C1 has been shown to interact with HDAC1,[3] Histone deacetylase 2,[3] OGT,[3] SIN3A,[4][3] SUDS3,[3] ZBTB17,[5] Sp1 transcription factor,[3][6] MLL,[4] PPP1CA,[7] POU2F1,[8][9] PDCD2,[10] WDR5,[4][3] CREB3[11][12] and GABPA.[13]

References

  1. ^ Wilson AC, LaMarco K, Peterson MG, Herr W (Aug 1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell 74 (1): 115–25. PMID 8392914. 
  2. ^ a b "Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054. 
  3. ^ a b c d e f g Wysocka, Joanna; Myers Michael P, Laherty Carol D, Eisenman Robert N, Herr Winship (Apr. 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. (United States) 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMID 12670868. 
  4. ^ a b c Yokoyama, Akihiko; Wang Zhong, Wysocka Joanna, Sanyal Mrinmoy, Aufiero Deborah J, Kitabayashi Issay, Herr Winship, Cleary Michael L (Jul. 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. (United States) 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMID 15199122. 
  5. ^ Piluso, David; Bilan Patricia, Capone John P (Nov. 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". J. Biol. Chem. (United States) 277 (48): 46799–808. doi:10.1074/jbc.M206226200. ISSN 0021-9258. PMID 12244100. 
  6. ^ Gunther, M; Laithier M, Brison O (Jul. 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. (NETHERLANDS) 210 (1-2): 131–42. ISSN 0300-8177. PMID 10976766. 
  7. ^ Ajuh, P M; Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I (Feb. 2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. (ENGLAND) 28 (3): 678–86. PMID 10637318. 
  8. ^ La Boissière, S; Hughes T, O'Hare P (Jan. 1999). "HCF-dependent nuclear import of VP16". EMBO J. (ENGLAND) 18 (2): 480–9. doi:10.1093/emboj/18.2.480. ISSN 0261-4189. PMID 9889203. 
  9. ^ Kristie, T M; Sharp P A (Mar. 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. (UNITED STATES) 268 (9): 6525–34. ISSN 0021-9258. PMID 8454622. 
  10. ^ Scarr, Rebecca B; Sharp Phillip A (Aug. 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene (England) 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. ISSN 0950-9232. PMID 12149646. 
  11. ^ Lu, R; Yang P, Padmakumar S, Misra V (Aug. 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. (UNITED STATES) 72 (8): 6291–7. ISSN 0022-538X. PMID 9658067. 
  12. ^ Freiman, R N; Herr W (Dec. 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. (UNITED STATES) 11 (23): 3122–7. ISSN 0890-9369. PMID 9389645. 
  13. ^ Vogel, J L; Kristie T M (Feb. 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. (ENGLAND) 19 (4): 683–90. doi:10.1093/emboj/19.4.683. ISSN 0261-4189. PMID 10675337. 

Further reading

  • Oehler T, Angel P (1992). "A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins.". Mol. Cell. Biol. 12 (12): 5508–15. PMID 1448082. 
  • Wilson AC, Peterson MG, Herr W (1995). "The HCF repeat is an unusual proteolytic cleavage signal.". Genes Dev. 9 (20): 2445–58. doi:10.1101/gad.9.20.2445. PMID 7590226. 
  • Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. doi:10.1073/pnas.92.13.5788. PMID 7597030. 
  • Frattini A, Faranda S, Redolfi E, et al. (1995). "Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28.". Genomics 23 (1): 30–5. doi:10.1006/geno.1994.1455. PMID 7829097. 
  • Kristie TM, Pomerantz JL, Twomey TC, et al. (1995). "The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.". J. Biol. Chem. 270 (9): 4387–94. doi:10.1074/jbc.270.9.4387. PMID 7876203. 
  • Kristie TM, Sharp PA (1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16).". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622. 
  • Zoppè M, Frattini A, Faranda S, Vezzoni P (1996). "The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression.". Genomics 34 (1): 85–91. doi:10.1006/geno.1996.0244. PMID 8661027. 
  • Wilson AC, Freiman RN, Goto H, et al. (1997). "VP16 targets an amino-terminal domain of HCF involved in cell cycle progression.". Mol. Cell. Biol. 17 (10): 6139–46. PMID 9315674. 
  • Freiman RN, Herr W (1998). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. PMID 9389645. 
  • Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF.". J. Virol. 72 (8): 6291–7. PMID 9658067. 
  • Ge H, Si Y, Roeder RG (1999). "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.". Embo J. 17 (22): 6723–9. doi:10.1093/emboj/17.22.6723. PMID 9822615. 
  • La Boissière S, Hughes T, O'Hare P (1999). "HCF-dependent nuclear import of VP16.". Embo J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMID 9889203. 
  • Lu R, Misra V (2000). "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency.". J. Virol. 74 (2): 934–43. doi:10.1128/JVI.74.2.934-943.2000. PMID 10623756. 
  • Mahajan SS, Wilson AC (2000). "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.". Mol. Cell. Biol. 20 (3): 919–28. doi:10.1128/MCB.20.3.919-928.2000. PMID 10629049. 
  • Ajuh PM, Browne GJ, Hawkes NA, et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex.". Nucleic Acids Res. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMID 10637318. 
  • Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.". Embo J. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMID 10675337. 
  • Scarr RB, Smith MR, Beddall M, Sharp PA (2000). "A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells.". Mol. Cell. Biol. 20 (10): 3568–75. doi:10.1128/MCB.20.10.3568-3575.2000. PMID 10779346. 
  • Choi Y, Asada S, Uesugi M (2000). "Divergent hTAFII31-binding motifs hidden in activation domains.". J. Biol. Chem. 275 (21): 15912–6. doi:10.1074/jbc.275.21.15912. PMID 10821850. 
  • Lu R, Misra V (2000). "Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16.". Nucleic Acids Res. 28 (12): 2446–54. doi:10.1093/nar/28.12.2446. PMID 10871379. 
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