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Hyperaldosteronism: Wikis


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Classification and external resources

ICD-10 E26.
ICD-9 255.1
OMIM 103900 605635
DiseasesDB 6187
MedlinePlus 000330
eMedicine radio/354
MeSH D006929

Hyperaldosteronism, also aldosteronism,[1] is a medical condition where too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood.



In endocrinology, the terms primary and secondary are used to describe the abnormality (e.g., elevated aldosterone) in relation to the defect, i.e., the tumor's location.

Primary (hyporeninemic hyperaldosteronism)

  • E26.0: Primary aldosteronism was previously thought to be most commonly caused by an adrenal adenoma, termed Conn's syndrome. However, recent studies have shown that bilateral idiopathic adrenal hyperplasia is the cause in up to 70% of cases. Differentiating between the two is important as this determines treatment. Adrenal carcinoma is an extremely rare cause of primary hyperaldosteronism.




  • adrenal adenoma: surgery
  • bilateral adrenocortical hyperplasia: aldosterone antagonist e.g. spironolactone

One form has been linked to 7p22.[2]

Secondary (hyperreninemic hyperaldosteronism)

Secondary refers to an abnormality that indirectly results in pathology through a predictable physiologic pathway, i.e., a renin producing tumor leads to increased aldosterone, as the body's aldosterone production is normally regulated by renin levels.

One cause is a juxtaglomerular cell tumor. Another is renal artery stenosis in which the reduced blood supply across the juxtaglomerular apparatus stimulates the production of renin.


It can be asymptomatic, but the following symptoms can be present

See also


Treatment includes Spironolactone, a K+ sparing diuretic that works by acting as an aldosterone antagonist.


External links



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