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Hypocretin (orexin) receptor 1
Identifiers
Symbols HCRTR1; OX1R
External IDs OMIM602392 MGI2385650 HomoloGene37492 IUPHAR: OX1 GeneCards: HCRTR1 Gene
RNA expression pattern
PBB GE HCRTR1 207619 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3061 230777
Ensembl ENSG00000121764 ENSMUSG00000028778
UniProt O43613 Q0VDP5
RefSeq (mRNA) NM_001525 XM_983697
RefSeq (protein) NP_001516 XP_988791
Location (UCSC) Chr 1:
31.86 - 31.87 Mb
Chr 4:
129.63 - 129.64 Mb
PubMed search [1] [2]

Hypocretin (orexin) receptor 1, also known as OX1, is a human protein encoded by the HCRTR1 gene.[1]

The orexin 1 receptor (OX1), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. OX1 selectively binds the orexin A neuropeptide. It shares 64% identity with OX2.[1]

Contents

Ligands

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Agonists

Antagonists

See also

References

External links

Further reading

  • Flier JS, Maratos-Flier E (1998). "Obesity and the hypothalamus: novel peptides for new pathways.". Cell 92 (4): 437–40. doi:10.1016/S0092-8674(00)80937-X. PMID 9491885.  
  • Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). "To eat or to sleep? Orexin in the regulation of feeding and wakefulness.". Annu. Rev. Neurosci. 24: 429–58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317.  
  • Hungs M, Mignot E (2001). "Hypocretin/orexin, sleep and narcolepsy.". Bioessays 23 (5): 397–408. doi:10.1002/bies.1058. PMID 11340621.  
  • de Lecea L, Kilduff TS, Peyron C, et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322–7. PMID 9419374.  
  • Sakurai T, Amemiya A, Ishii M, et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.". Cell 92 (4): 573–85. doi:10.1016/S0092-8674(00)80949-6. PMID 9491897.  
  • Sakurai T, Amemiya A, Ishii M, et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.". Cell 92 (5): 1 page following 696. doi:10.1016/S0092-8674(00)80949-6. PMID 9527442.  
  • Peyron C, Faraco J, Rogers W, et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.". Nat. Med. 6 (9): 991–7. doi:10.1038/79690. PMID 10973318.  
  • Blanco M, López M, GarcIa-Caballero T, et al. (2001). "Cellular localization of orexin receptors in human pituitary.". J. Clin. Endocrinol. Metab. 86 (7): 1616–9. doi:10.1210/jc.86.4.1616. PMID 11443222.  
  • Olafsdóttir BR, Rye DB, Scammell TE, et al. (2002). "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.". Neurology 57 (10): 1896–9. PMID 11723285.  
  • Wieland HA, Söll RM, Doods HN, et al. (2002). "The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor.". Eur. J. Biochem. 269 (4): 1128–35. doi:10.1046/j.0014-2956.2001.02739.x. PMID 11856342.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hilairet S, Bouaboula M, Carrière D, et al. (2003). "Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.". J. Biol. Chem. 278 (26): 23731–7. doi:10.1074/jbc.M212369200. PMID 12690115.  
  • Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. doi:10.1210/jc.2003-031778. PMID 15070969.  
  • Holmqvist T, Johansson L, Ostman M, et al. (2005). "OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.". J. Biol. Chem. 280 (8): 6570–9. doi:10.1074/jbc.M407397200. PMID 15611118.  
  • Spinazzi R, Rucinski M, Neri G, et al. (2005). "Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.". J. Clin. Endocrinol. Metab. 90 (6): 3544–9. doi:10.1210/jc.2004-2385. PMID 15797953.  
  • Meerabux J, Iwayama Y, Sakurai T, et al. (2005). "Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.". Biol. Psychiatry 58 (5): 401–7. doi:10.1016/j.biopsych.2005.04.015. PMID 15978554.  
  • Ziolkowska A, Spinazzi R, Albertin G, et al. (2006). "Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor.". J. Steroid Biochem. Mol. Biol. 96 (5): 423–9. doi:10.1016/j.jsbmb.2005.05.003. PMID 16157481.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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