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From Wikipedia, the free encyclopedia

Inducible T-cell co-stimulator ligand
Symbols ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; KIAA0653; LICOS
External IDs OMIM605717 MGI1354701 HomoloGene49412 GeneCards: ICOSLG Gene
RNA expression pattern
PBB GE ICOSLG 211199 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23308 50723
Ensembl ENSG00000160223 ENSMUSG00000000732
UniProt O75144 Q3UWV7
RefSeq (mRNA) NM_015259 NM_015790
RefSeq (protein) NP_056074 NP_056605
Location (UCSC) Chr 21:
44.47 - 44.49 Mb
Chr 10:
77.47 - 77.48 Mb
PubMed search [1] [2]

ICOS ligand is a protein that in humans is encoded by the ICOSLG gene.[1][2][3] ICOSLG has also been designated as CD275 (cluster of differentiation 275).


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169-76. PMID 9734811.  
  2. ^ Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T, Delaney J, Han H, Hui A, Kohno T, Manoukian R, Whoriskey JS, Coccia MA (Nov 2000). "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS". Int Immunol 12 (10): 1439-47. PMID 11007762.  
  3. ^ "Entrez Gene: ICOSLG inducible T-cell co-stimulator ligand".  

Further reading

  • Flesch IE (2003). "Inducible costimulator-ligand (ICOS-L).". J. Biol. Regul. Homeost. Agents 16 (3): 217–9. PMID 12456022.  
  • Ling V, Wu PW, Finnerty HF, et al. (2000). "Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor.". J. Immunol. 164 (4): 1653–7. PMID 10657606.  
  • Aicher A, Hayden-Ledbetter M, Brady WA, et al. (2000). "Characterization of human inducible costimulator ligand expression and function.". J. Immunol. 164 (9): 4689–96. PMID 10779774.  
  • Wang S, Zhu G, Chapoval AI, et al. (2000). "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.". Blood 96 (8): 2808–13. PMID 11023515.  
  • Ling V, Wu PW, Miyashiro JS, et al. (2001). "Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules.". J. Immunol. 166 (12): 7300–8. PMID 11390480.  
  • Sperling AI, Bluestone JA (2001). "ICOS costimulation: It's not just for TH2 cells anymore.". Nat. Immunol. 2 (7): 573–4. doi:10.1038/89709. PMID 11429535.  
  • Wang S, Zhu G, Tamada K, et al. (2002). "Ligand binding sites of inducible costimulator and high avidity mutants with improved function.". J. Exp. Med. 195 (8): 1033–41. doi:10.1084/jem.20011607. PMID 11956294.  
  • Khayyamian S, Hutloff A, Büchner K, et al. (2002). "ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6198–203. doi:10.1073/pnas.092576699. PMID 11983910.  
  • Akbari O, Freeman GJ, Meyer EH, et al. (2002). "Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.". Nat. Med. 8 (9): 1024–32. doi:10.1038/nm745. PMID 12145647.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kurosawa S, Myers AC, Chen L, et al. (2003). "Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.". Am. J. Respir. Cell Mol. Biol. 28 (5): 563–73. doi:10.1165/rcmb.2002-0199OC. PMID 12707012.  
  • Chen XL, Cao XD, Kang AJ, et al. (2003). "In situ expression and significance of B7 costimulatory molecules within tissues of human gastric carcinoma.". World J. Gastroenterol. 9 (6): 1370–3. PMID 12800259.  
  • Iwai H, Abe M, Hirose S, et al. (2003). "Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.". J. Immunol. 171 (6): 2848–54. PMID 12960306.  
  • Schreiner B, Wischhusen J, Mitsdoerffer M, et al. (2004). "Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo.". Glia 44 (3): 296–301. doi:10.1002/glia.10291. PMID 14603470.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Saatian B, Yu XY, Yu X, et al. (2004). "Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation.". Am. J. Physiol. Lung Cell Mol. Physiol. 287 (1): L217–25. doi:10.1152/ajplung.00132.2003. PMID 15047568.  
  • Nakazawa A, Dotan I, Brimnes J, et al. (2004). "The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells.". Gastroenterology 126 (5): 1347–57. doi:10.1053/j.gastro.2004.02.004. PMID 15131796.  

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