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IFI16: Wikis


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Interferon, gamma-inducible protein 16

PDB rendering based on 2oq0.
Available structures
Symbols IFI16; IFNGIP1; MGC9466; PYHIN2
External IDs OMIM147586 MGI96429 HomoloGene48354 GeneCards: IFI16 Gene
RNA expression pattern
PBB GE IFI16 206332 s at tn.png
PBB GE IFI16 208965 s at tn.png
PBB GE IFI16 208966 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3428 15951
Ensembl ENSG00000163565 ENSMUSG00000054203
UniProt Q16666 Q3TM07
RefSeq (mRNA) NM_005531 XM_001002287
RefSeq (protein) NP_005522 XP_001002287
Location (UCSC) Chr 1:
157.24 - 157.29 Mb
Chr 1:
175.85 - 175.87 Mb
PubMed search [1] [2]

Gamma-interferon-inducible protein Ifi-16 is a protein that in humans is encoded by the IFI16 gene.[1][2][3]

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.[3]


  1. ^ Trapani JA, Browne KA, Dawson MJ, Ramsay RG, Eddy RL, Show TB, White PC, Dupont B (Oct 1992). "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics 36 (6): 369-76. PMID 1526658.  
  2. ^ Trapani JA, Dawson M, Apostolidis VA, Browne KA (Dec 1994). "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics 40 (6): 415-24. PMID 7959953.  
  3. ^ a b "Entrez Gene: IFI16 interferon, gamma-inducible protein 16".  

Further reading

  • Dawson MJ, Trapani JA (1995). "IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.". J. Cell. Biochem. 57 (1): 39–51. doi:10.1002/jcb.240570106. PMID 7536752.  
  • Dawson MJ, Trapani JA, Briggs RC, et al. (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression.". Immunogenetics 41 (1): 40–3. doi:10.1007/BF00188431. PMID 7806273.  
  • Johnstone RW, Kerry JA, Trapani JA (1998). "The human interferon-inducible protein, IFI 16, is a repressor of transcription.". J. Biol. Chem. 273 (27): 17172–7. doi:10.1074/jbc.273.27.17172. PMID 9642285.  
  • Johnstone RW, Kershaw MH, Trapani JA (1998). "Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing.". Biochemistry 37 (34): 11924–31. doi:10.1021/bi981069a. PMID 9718316.  
  • Dawson MJ, Elwood NJ, Johnstone RW, Trapani JA (1998). "The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.". J. Leukoc. Biol. 64 (4): 546–54. PMID 9766636.  
  • Briggs LJ, Johnstone RW, Elliot RM, et al. (2001). "Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16.". Biochem. J. 353 (Pt 1): 69–77. doi:10.1042/0264-6021:3530069. PMID 11115400.  
  • Johnstone RW, Wei W, Greenway A, Trapani JA (2001). "Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.". Oncogene 19 (52): 6033–42. doi:10.1038/sj.onc.1204005. PMID 11146555.  
  • Gariglio M, Azzimonti B, Pagano M, et al. (2003). "Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells.". J. Interferon Cytokine Res. 22 (7): 815–21. doi:10.1089/107999002320271413. PMID 12184920.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.  
  • Clarke CJ, Apostolidis V, Hii LL, et al. (2003). "Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16.". J. Cell. Biochem. 89 (1): 80–93. doi:10.1002/jcb.10475. PMID 12682910.  
  • Xin H, Curry J, Johnstone RW, et al. (2003). "Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.". Oncogene 22 (31): 4831–40. doi:10.1038/sj.onc.1206754. PMID 12894224.  
  • Kwak JC, Ongusaha PP, Ouchi T, Lee SW (2003). "IFI16 as a negative regulator in the regulation of p53 and p21(Waf1).". J. Biol. Chem. 278 (42): 40899–904. doi:10.1074/jbc.M308012200. PMID 12925527.  
  • Aglipay JA, Lee SW, Okada S, et al. (2004). "A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.". Oncogene 22 (55): 8931–8. doi:10.1038/sj.onc.1207057. PMID 14654789.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Raffaella R, Gioia D, De Andrea M, et al. (2004). "The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells.". Exp. Cell Res. 293 (2): 331–45. doi:10.1016/j.yexcr.2003.10.014. PMID 14729471.  
  • Fujiuchi N, Aglipay JA, Ohtsuka T, et al. (2004). "Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.". J. Biol. Chem. 279 (19): 20339–44. doi:10.1074/jbc.M400344200. PMID 14990579.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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