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IFITM1: Wikis


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Interferon induced transmembrane protein 1 (9-27)
Symbols IFITM1; 9-27; CD225; IFI17; LEU13
External IDs OMIM604456 HomoloGene74501 GeneCards: IFITM1 Gene
RNA expression pattern
PBB GE IFITM1 214022 s at tn.png
PBB GE IFITM1 201601 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8519 n/a
Ensembl ENSG00000185885 n/a
UniProt P13164 n/a
RefSeq (mRNA) NM_003641 n/a
RefSeq (protein) NP_003632 n/a
Location (UCSC) Chr 11:
0.3 - 0.31 Mb
PubMed search [1] n/a

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene.[1][2] IFITM1 has also recently been designated CD225 (cluster of differentiation 225).

This protein has several additional names: fragilis (human homolog of the mouse protein), IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13


Molecular biology

The gene is located on the Watson (plus) strand of the short arm of chromosome 11 (11p15.5) and is 3,956 bases in length. The encoded protein has 125 amino acids (molecular weight 13.964 kDa).

It is an intrinic membrane protein and is predicted to cross the membrane several times.


The gene is induced by interferon and the protein forms part of the signaling pathway.


  1. ^ Deblandre GA, Marinx OP, Evans SS, Majjaj S, Leo O, Caput D, Huez GA, Wathelet MG (Nov 1995). "Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth". J Biol Chem 270 (40): 23860-6. PMID 7559564.  
  2. ^ "Entrez Gene: IFITM1 interferon induced transmembrane protein 1 (9-27)".  

Further reading

  • Bradbury LE, Kansas GS, Levy S, et al. (1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.". J. Immunol. 149 (9): 2841–50. PMID 1383329.  
  • Takahashi S, Doss C, Levy S, Levy R (1990). "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen.". J. Immunol. 145 (7): 2207–13. PMID 2398277.  
  • Reid LE, Brasnett AH, Gilbert CS, et al. (1989). "A single DNA response element can confer inducibility by both alpha- and gamma-interferons.". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 840–4. doi:10.1073/pnas.86.3.840. PMID 2492664.  
  • Kelly JM, Gilbert CS, Stark GR, Kerr IM (1986). "Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons.". Eur. J. Biochem. 153 (2): 367–71. doi:10.1111/j.1432-1033.1985.tb09312.x. PMID 3935435.  
  • Friedman RL, Manly SP, McMahon M, et al. (1984). "Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.". Cell 38 (3): 745–55. doi:10.1016/0092-8674(84)90270-8. PMID 6548414.  
  • Constantoulakis P, Campbell M, Felber BK, et al. (1993). "Inhibition of Rev-mediated HIV-1 expression by an RNA binding protein encoded by the interferon-inducible 9-27 gene.". Science 259 (5099): 1314–8. doi:10.1126/science.7680491. PMID 7680491.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kita K, Sugaya S, Zhai L, et al. (2003). "Involvement of LEU13 in interferon-induced refractoriness of human RSa cells to cell killing by X rays.". Radiat. Res. 160 (3): 302–8. doi:10.1667/RR3039. PMID 12926988.  
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Akyerli CB, Beksac M, Holko M, et al. (2005). "Expression of IFITM1 in chronic myeloid leukemia patients.". Leuk. Res. 29 (3): 283–6. doi:10.1016/j.leukres.2004.07.007. PMID 15661263.  
  • Yang Y, Lee JH, Kim KY, et al. (2005). "The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells.". Cancer Lett. 221 (2): 191–200. doi:10.1016/j.canlet.2004.08.022. PMID 15808405.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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