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Insulin-like growth factor binding protein 7
Symbols IGFBP7; FSTL2; IGFBP-7; IGFBP-7v; MAC25; PSF
External IDs OMIM602867 MGI1352480 HomoloGene1193 GeneCards: IGFBP7 Gene
RNA expression pattern
PBB GE IGFBP7 201163 s at tn.png
PBB GE IGFBP7 201162 at tn.png
More reference expression data
Species Human Mouse
Entrez 3490 29817
Ensembl ENSG00000163453 ENSMUSG00000036256
UniProt Q16270 A0A5E1
RefSeq (mRNA) NM_001553 NM_008048
RefSeq (protein) NP_001544 NP_032074
Location (UCSC) Chr 4:
57.59 - 57.67 Mb
Chr 5:
78.42 - 78.48 Mb
PubMed search [1] [2]

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene.[1][2][3]


IGFBP7 has been shown to interact with Insulin-like growth factor 1[4][5] and VPS24.[6]


  1. ^ Murphy M, Pykett MJ, Harnish P, Zang KD, George DL (Dec 1993). "Identification and characterization of genes differentially expressed in meningiomas". Cell Growth Differ 4 (9): 715–22. PMID 7694637.  
  2. ^ Yamauchi T, Umeda F, Masakado M, Isaji M, Mizushima S, Nawata H (Nov 1994). "Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells". Biochem J 303 ( Pt 2): 591–8. PMID 7980422.  
  3. ^ "Entrez Gene: IGFBP7 insulin-like growth factor binding protein 7".  
  4. ^ Ahmed, Sanjida; Yamamoto Kazuhiro, Sato Yuichiro, Ogawa Takashi, Herrmann Andreas, Higashi Shouichi, Miyazaki Kaoru (Oct. 2003). "Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity". Biochem. Biophys. Res. Commun. (United States) 310 (2): 612–8. ISSN 0006-291X. PMID 14521955.  
  5. ^ Oh, Y; Nagalla S R, Yamanaka Y, Kim H S, Wilson E, Rosenfeld R G (Nov. 1996). "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II". J. Biol. Chem. (UNITED STATES) 271 (48): 30322–5. ISSN 0021-9258. PMID 8939990.  
  6. ^ Wilson, E M; Oh Y, Hwa V, Rosenfeld R G (Sep. 2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells". J. Clin. Endocrinol. Metab. (United States) 86 (9): 4504–11. ISSN 0021-972X. PMID 11549700.  

Further reading

  • Swisshelm K, Ryan K, Tsuchiya K, Sager R (1995). "Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid.". Proc. Natl. Acad. Sci. U.S.A. 92 (10): 4472–6. doi:10.1073/pnas.92.10.4472. PMID 7538673.  
  • Oh Y, Nagalla SR, Yamanaka Y, et al. (1997). "Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.". J. Biol. Chem. 271 (48): 30322–5. doi:10.1074/jbc.271.48.30322. PMID 8939990.  
  • Wilson EM, Oh Y, Rosenfeld RG (1997). "Generation and characterization of an IGFBP-7 antibody: identification of 31kD IGFBP-7 in human biological fluids and Hs578T human breast cancer conditioned media.". J. Clin. Endocrinol. Metab. 82 (4): 1301–3. doi:10.1210/jc.82.4.1301. PMID 9100611.  
  • Sekiguchi N, Umeda F, Masakado M, et al. (1997). "Immunohistochemical study of prostacyclin-stimulating factor (PSF) in the diabetic and atherosclerotic human coronary artery.". Diabetes 46 (10): 1627–32. doi:10.2337/diabetes.46.10.1627. PMID 9313760.  
  • Yamanaka Y, Wilson EM, Rosenfeld RG, Oh Y (1998). "Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.". J. Biol. Chem. 272 (49): 30729–34. doi:10.1074/jbc.272.49.30729. PMID 9388210.  
  • Sato J, Hasegawa S, Akaogi K, et al. (1999). "Identification of cell-binding site of angiomodulin (AGM/TAF/Mac25) that interacts with heparan sulfates on cell surface.". J. Cell. Biochem. 75 (2): 187–95. doi:10.1002/(SICI)1097-4644(19991101)75:2<187::AID-JCB1>3.0.CO;2-R. PMID 10502291.  
  • Girard JP, Baekkevold ES, Yamanaka T, et al. (1999). "Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization.". Am. J. Pathol. 155 (6): 2043–55. PMID 10595934.  
  • Degeorges A, Wang F, Frierson HF, et al. (2000). "Distribution of IGFBP-rP1 in normal human tissues.". J. Histochem. Cytochem. 48 (6): 747–54. PMID 10820148.  
  • Kato MV (2000). "A secreted tumor-suppressor, mac25, with activin-binding activity.". Mol. Med. 6 (2): 126–35. PMID 10859029.  
  • Allen JT, Bloor CA, Kedia RK, et al. (2001). "Expression of growth hormone-releasing factor, growth hormone, insulin-like growth factor-1 and its binding proteins in human lung.". Neuropeptides 34 (2): 98–107. doi:10.1054/npep.2000.0802. PMID 10985926.  
  • Wilson EM, Oh Y, Hwa V, Rosenfeld RG (2001). "Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells.". J. Clin. Endocrinol. Metab. 86 (9): 4504–11. doi:10.1210/jc.86.9.4504. PMID 11549700.  
  • Wilson HM, Birnbaum RS, Poot M, et al. (2002). "Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism.". Cell Growth Differ. 13 (5): 205–13. PMID 12065244.  
  • Usui T, Murai T, Tanaka T, et al. (2003). "Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells.". Int. Immunol. 14 (11): 1273–82. doi:10.1093/intimm/dxf102. PMID 12407018.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Plymate SR, Haugk KH, Sprenger CC, et al. (2003). "Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1.". Oncogene 22 (7): 1024–34. doi:10.1038/sj.onc.1206210. PMID 12592389.  
  • Domínguez F, Avila S, Cervero A, et al. (2003). "A combined approach for gene discovery identifies insulin-like growth factor-binding protein-related protein 1 as a new gene implicated in human endometrial receptivity.". J. Clin. Endocrinol. Metab. 88 (4): 1849–57. doi:10.1210/jc.2002-020724. PMID 12679483.  
  • López-Bermejo A, Khosravi J, Corless CL, et al. (2003). "Generation of anti-insulin-like growth factor-binding protein-related protein 1 (IGFBP-rP1/MAC25) monoclonal antibodies and immunoassay: quantification of IGFBP-rP1 in human serum and distribution in human fluids and tissues.". J. Clin. Endocrinol. Metab. 88 (7): 3401–8. doi:10.1210/jc.2002-021315. PMID 12843194.  
  • Nagakubo D, Murai T, Tanaka T, et al. (2003). "A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines.". J. Immunol. 171 (2): 553–61. PMID 12847218.  


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