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Immunoglobulin superfamily, member 8
Symbols IGSF8; CD316; CD81P3; EWI2; PGRL
External IDs OMIM606644 MGI2154090 HomoloGene14163 GeneCards: IGSF8 Gene
Species Human Mouse
Entrez 93185 140559
Ensembl ENSG00000162729 ENSMUSG00000038034
UniProt Q969P0 Q8R366
RefSeq (mRNA) NM_052868 NM_080419
RefSeq (protein) NP_443100 NP_536344
Location (UCSC) Chr 1:
158.33 - 158.34 Mb
Chr 1:
174.1 - 174.16 Mb
PubMed search [1] [2]

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.[1][2][3]IGSF8 has also been designated as CD316 (cluster of differentiation 316).


  1. ^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem 276 (44): 40545-54. doi:10.1074/jbc.M107338200. PMID 11504738.  
  2. ^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol 167 (9): 5115-21. PMID 11673522.  
  3. ^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".  

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells.". Biochem. J. 373 (Pt 2): 409–21. doi:10.1042/BJ20030343. PMID 12708969.  
  • Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.". Cancer Res. 63 (10): 2665–74. PMID 12750295.  
  • Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121.  
  • Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5.". J. Cell Biol. 163 (5): 1167–77. doi:10.1083/jcb.200309113. PMID 14662754.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions.". Blood 103 (8): 3013–9. doi:10.1182/blood-2003-07-2201. PMID 15070678.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.". J. Biol. Chem. 281 (18): 12976–85. doi:10.1074/jbc.M510617200. PMID 16537545.  
  • Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.". J. Biol. Chem. 281 (28): 19665–75. doi:10.1074/jbc.M602116200. PMID 16690612.  
  • Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells.". Mol. Cell. Biol. 27 (21): 7718–26. doi:10.1128/MCB.00180-07. PMID 17785435.  

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