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IKBKE: Wikis


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Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Symbols IKBKE; IKK-i; IKKE; IKKI; KIAA0151; MGC125294; MGC125295; MGC125297
External IDs OMIM605048 MGI1929612 HomoloGene23168 GeneCards: IKBKE Gene
RNA expression pattern
PBB GE IKBKE 214398 s at tn.png
PBB GE IKBKE 204549 at tn.png
More reference expression data
Species Human Mouse
Entrez 9641 56489
Ensembl ENSG00000143466 ENSMUSG00000042349
UniProt Q14164 Q5DU46
RefSeq (mRNA) NM_014002 NM_019777
RefSeq (protein) NP_054721 NP_062751
Location (UCSC) Chr 1:
204.71 - 204.74 Mb
Chr 1:
133.08 - 133.11 Mb
PubMed search [1] [2]

Inhibitor of nuclear factor kappa-B kinase subunit epsilon is an enzyme that in humans is encoded by the IKBKE gene.[1][2][3]


IKBKE has been shown to interact with TANK.[4]


  1. ^ Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S (Sep 1999). "IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases". Int Immunol 11 (8): 1357–62. PMID 10421793.  
  2. ^ Peters RT, Liao SM, Maniatis T (Jul 2000). "IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex". Mol Cell 5 (3): 513–22. PMID 10882136.  
  3. ^ "Entrez Gene: IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon".  
  4. ^ Nomura, F; Kawai T, Nakanishi K, Akira S (Mar. 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes Cells (ENGLAND) 5 (3): 191–202. ISSN 1356-9597. PMID 10759890.  

Further reading

  • Mercurio AM (2003). "Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way.". Cancer Cell 3 (3): 201–2. doi:10.1016/S1535-6108(03)00049-7. PMID 12676577.  
  • Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.  
  • Nomura F, Kawai T, Nakanishi K, Akira S (2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.". Genes Cells 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890.  
  • Miller BS, Zandi E (2001). "Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation.". J. Biol. Chem. 276 (39): 36320–6. doi:10.1074/jbc.M104051200. PMID 11470787.  
  • Kishore N, Huynh QK, Mathialagan S, et al. (2002). "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.". J. Biol. Chem. 277 (16): 13840–7. doi:10.1074/jbc.M110474200. PMID 11839743.  
  • Aupperle KR, Yamanishi Y, Bennett BL, et al. (2002). "Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes.". Cell. Immunol. 214 (1): 54–9. doi:10.1006/cimm.2002.1885. PMID 11902829.  
  • Bossis G, Salinas S, Cartier C, et al. (2002). "NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases.". FEBS Lett. 516 (1-3): 257–64. doi:10.1016/S0014-5793(02)02566-8. PMID 11959143.  
  • Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.". J. Biol. Chem. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fitzgerald KA, McWhirter SM, Faia KL, et al. (2003). "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.". Nat. Immunol. 4 (5): 491–6. doi:10.1038/ni921. PMID 12692549.  
  • Kravchenko VV, Mathison JC, Schwamborn K, et al. (2003). "IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli.". J. Biol. Chem. 278 (29): 26612–9. doi:10.1074/jbc.M303001200. PMID 12736252.  
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.  
  • Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMID 14560022.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.  
  • tenOever BR, Sharma S, Zou W, et al. (2004). "Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.". J. Virol. 78 (19): 10636–49. doi:10.1128/JVI.78.19.10636-10649.2004. PMID 15367631.  
  • Buss H, Dörrie A, Schmitz ML, et al. (2005). "Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.". J. Biol. Chem. 279 (53): 55633–43. doi:10.1074/jbc.M409825200. PMID 15489227.  


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