The Full Wiki

IKZF1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
IKAROS family zinc finger 1 (Ikaros)
Identifiers
Symbols IKZF1; IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1
External IDs OMIM603023 MGI1342540 HomoloGene55948 GeneCards: IKZF1 Gene
RNA expression pattern
PBB GE IKZF1 205039 s at tn.png
PBB GE IKZF1 216901 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10320 22778
Ensembl ENSG00000185811 ENSMUSG00000018654
UniProt Q13422 Q5GGW4
RefSeq (mRNA) NM_006060 NM_001025597
RefSeq (protein) NP_006051 NP_001020768
Location (UCSC) Chr 7:
50.31 - 50.44 Mb
Chr 11:
11.59 - 11.67 Mb
PubMed search [1] [2]

DNA-binding protein Ikaros is a protein that in humans is encoded by the IKZF1 gene.[1][2][3]

Contents

Interactions

IKZF1 has been shown to interact with Histone deacetylase 5,[4] HDAC1,[5][4] HDAC7A,[4] SIN3B,[5][4] SIN3A,[6][5][4] IKZF4[7][8] and CTBP1.[9]

References

  1. ^ Georgopoulos K, Moore DD, Derfler B (Dec 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment". Science 258 (5083): 808–12. PMID 1439790.  
  2. ^ Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (Nov 1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene". Mol Cell Biol 14 (11): 7111–23. PMID 7935426.  
  3. ^ "Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10320.  
  4. ^ a b c d e Koipally, Joseph; Georgopoulos Katia (Aug. 2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. (United States) 277 (31): 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313.  
  5. ^ a b c Koipally, J; Renold A, Kim J, Georgopoulos K (Jun. 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". EMBO J. (ENGLAND) 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. ISSN 0261-4189. PMID 10357820.  
  6. ^ Koipally, Joseph; Georgopoulos Katia (Jun. 2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression". J. Biol. Chem. (United States) 277 (26): 23143–9. doi:10.1074/jbc.M202079200. ISSN 0021-9258. PMID 11959865.  
  7. ^ Honma, Y; Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A (Mar. 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. (NETHERLANDS) 447 (1): 76–80. ISSN 0014-5793. PMID 10218586.  
  8. ^ Perdomo, J; Holmes M, Chong B, Crossley M (Dec. 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J. Biol. Chem. (UNITED STATES) 275 (49): 38347–54. doi:10.1074/jbc.M005457200. ISSN 0021-9258. PMID 10978333.  
  9. ^ Koipally, J; Georgopoulos K (Jun. 2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". J. Biol. Chem. (UNITED STATES) 275 (26): 19594–602. doi:10.1074/jbc.M000254200. ISSN 0021-9258. PMID 10766745.  

Further reading

  • Tonnelle C, Calmels B, Maroc C, et al. (2003). "Ikaros gene expression and leukemia.". Leuk. Lymphoma 43 (1): 29–35. doi:10.1080/10428190210186. PMID 11908734.  
  • Westman BJ, Mackay JP, Gell D (2002). "Ikaros: a key regulator of haematopoiesis.". Int. J. Biochem. Cell Biol. 34 (10): 1304–7. doi:10.1016/S1357-2725(02)00070-5. PMID 12127581.  
  • Molnár A, Wu P, Largespada DA, et al. (1996). "The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.". J. Immunol. 156 (2): 585–92. PMID 8543809.  
  • Nietfeld W, Meyerhans A (1996). "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1.". Immunol. Lett. 49 (1-2): 139–41. doi:10.1016/0165-2478(95)02479-4. PMID 8964602.  
  • Morgan B, Sun L, Avitahl N, et al. (1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.". EMBO J. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMID 9155026.  
  • Kelley CM, Ikeda T, Koipally J, et al. (1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.". Curr. Biol. 8 (9): 508–15. doi:10.1016/S0960-9822(98)70202-7. PMID 9560339.  
  • Sun L, Heerema N, Crotty L, et al. (1999). "Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 680–5. doi:10.1073/pnas.96.2.680. PMID 9892693.  
  • Kim J, Sif S, Jones B, et al. (1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.". Immunity 10 (3): 345–55. doi:10.1016/S1074-7613(00)80034-5. PMID 10204490.  
  • Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system.". FEBS Lett. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. PMID 10218586.  
  • Koipally J, Renold A, Kim J, Georgopoulos K (1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.". EMBO J. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMID 10357820.  
  • Sun L, Goodman PA, Wood CM, et al. (2000). "Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia.". J. Clin. Oncol. 17 (12): 3753–66. PMID 10577847.  
  • Hosokawa Y, Maeda Y, Ichinohasama R, et al. (2000). "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma.". Blood 95 (8): 2719–21. PMID 10753856.  
  • Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.". J. Biol. Chem. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.  
  • Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.". J. Biol. Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.  
  • Payne KJ, Nicolas JH, Zhu JY, et al. (2001). "Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis.". J. Immunol. 167 (4): 1867–70. PMID 11489963.  
  • Koipally J, Heller EJ, Seavitt JR, Georgopoulos K (2002). "Unconventional potentiation of gene expression by Ikaros.". J. Biol. Chem. 277 (15): 13007–15. doi:10.1074/jbc.M111371200. PMID 11799125.  
  • Dorsam G, Goetzl EJ (2002). "Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros.". J. Biol. Chem. 277 (16): 13488–93. doi:10.1074/jbc.M107922200. PMID 11812772.  

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message