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IKAROS family zinc finger 2 (Helios)
Identifiers
Symbols IKZF2; HELIOS; MGC34330; ZNF1A2; ZNFN1A2
External IDs OMIM606234 MGI1342541 HomoloGene22659 GeneCards: IKZF2 Gene
RNA expression pattern
PBB GE IKZF2 220567 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22807 22779
Ensembl ENSG00000030419 ENSMUSG00000025997
UniProt Q9UKS7 Q8C8A3
RefSeq (mRNA) NM_001079526 NM_011770
RefSeq (protein) NP_001072994 NP_035900
Location (UCSC) Chr 2:
213.58 - 213.72 Mb
Chr 1:
69.47 - 69.62 Mb
PubMed search [1] [2]

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.[1][2][3]

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]

References

  1. ^ Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST (Apr 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes Dev 12 (6): 782-96. PMID 9512513.  
  2. ^ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Aug 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Curr Biol 8 (9): 508-15. PMID 9560339.  
  3. ^ a b "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22807.  

Further reading

  • Rebollo A, Schmitt C (2004). "Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies.". Immunol. Cell Biol. 81 (3): 171–5. doi:10.1046/j.1440-1711.2003.01159.x. PMID 12752680.  
  • Sridharan R, Smale ST (2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.". J. Biol. Chem. 282 (41): 30227–38. doi:10.1074/jbc.M702541200. PMID 17681952.  
  • Tabayashi T, Ishimaru F, Takata M, et al. (2007). "Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies.". Cancer Sci. 98 (2): 182–8. doi:10.1111/j.1349-7006.2006.00372.x. PMID 17297655.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Sun L, Kerawalla H, Wu X, et al. (2002). "Expression of a unique helios isoform in human leukemia cells.". Leuk. Lymphoma 43 (4): 841–9. doi:10.1080/10428190290016980. PMID 12153174.  
  • Durand C, Kerfourn F, Charlemagne J, Fellah JS (2002). "Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors.". Eur. J. Immunol. 32 (6): 1748–52. doi:10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B. PMID 12115658.  
  • Nakase K, Ishimaru F, Fujii K, et al. (2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.". Exp. Hematol. 30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.  
  • Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.". J. Biol. Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.  
  • Hosokawa Y, Maeda Y, Seto M (1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern.". Immunogenetics 50 (1-2): 106–8. doi:10.1007/s002510050696. PMID 10541817.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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