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Interleukin 18 receptor 1
Identifiers
Symbols IL18R1; CDw218a; IL-1Rrp; IL1RRP
External IDs OMIM604494 MGI105383 HomoloGene2861 GeneCards: IL18R1 Gene
RNA expression pattern
PBB GE IL18R1 206618 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8809 16182
Ensembl ENSG00000115604 ENSMUSG00000026070
UniProt Q13478 Q8C257
RefSeq (mRNA) NM_003855 NM_008365
RefSeq (protein) NP_003846 NP_032391
Location (UCSC) Chr 2:
102.35 - 102.38 Mb
Chr 1:
40.41 - 40.45 Mb
PubMed search [1] [2]

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]

Contents

See also

References

Further reading

  • Sergi B, Penttila I (2005). "Interleukin 18 receptor.". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.  
  • Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.  
  • Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.  
  • Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor.". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.  
  • Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.  
  • Hoshino K, Tsutsui H, Kawai T, et al. (1999). "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.". J. Immunol. 162 (9): 5041–4. PMID 10227969.  
  • Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.". J. Immunol. 165 (4): 1933–8. PMID 10925275.  
  • Kumar S, Hanning CR, Brigham-Burke MR, et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.". Cytokine 18 (2): 61–71. doi:10.1006/cyto.2002.0873. PMID 12096920.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gutzmer R, Langer K, Mommert S, et al. (2004). "Human dendritic cells express the IL-18R and are chemoattracted to IL-18.". J. Immunol. 171 (12): 6363–71. PMID 14662834.  
  • Azam T, Novick D, Bufler P, et al. (2004). "Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.". J. Immunol. 171 (12): 6574–80. PMID 14662859.  
  • Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.  
  • Cardoso SP, Keen L, Bidwell J (2004). "Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha.". Eur. J. Immunogenet. 31 (1): 27–9. doi:10.1111/j.1365-2370.2004.00441.x. PMID 15009178.  
  • Reddy SA, Lin YF, Huang HJ, et al. (2004). "The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation.". Biochem. Biophys. Res. Commun. 316 (4): 1022–8. doi:10.1016/j.bbrc.2004.02.155. PMID 15044087.  
  • Yoon- DY, Cho YS, Park JW, et al. (2005). "Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor.". Clin. Chem. Lab. Med. 42 (5): 499–506. doi:10.1515/CCLM.2004.085. PMID 15202785.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Sahar S, Dwarakanath RS, Reddy MA, et al. (2005). "Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis.". Circ. Res. 96 (10): 1064–71. doi:10.1161/01.RES.0000168210.10358.f4. PMID 15860756.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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