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Interleukin 18 receptor 1
Symbols IL18R1; CDw218a; IL-1Rrp; IL1RRP
External IDs OMIM604494 MGI105383 HomoloGene2861 GeneCards: IL18R1 Gene
RNA expression pattern
PBB GE IL18R1 206618 at tn.png
More reference expression data
Species Human Mouse
Entrez 8809 16182
Ensembl ENSG00000115604 ENSMUSG00000026070
UniProt Q13478 Q8C257
RefSeq (mRNA) NM_003855 NM_008365
RefSeq (protein) NP_003846 NP_032391
Location (UCSC) Chr 2:
102.35 - 102.38 Mb
Chr 1:
40.41 - 40.45 Mb
PubMed search [1] [2]

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]


See also


Further reading

  • Sergi B, Penttila I (2005). "Interleukin 18 receptor.". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.  
  • Parnet P, Garka KE, Bonnert TP, et al. (1996). "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.". J. Biol. Chem. 271 (8): 3967–70. doi:10.1074/jbc.271.8.3967. PMID 8626725.  
  • Lovenberg TW, Crowe PD, Liu C, et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2).". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.  
  • Torigoe K, Ushio S, Okura T, et al. (1997). "Purification and characterization of the human interleukin-18 receptor.". J. Biol. Chem. 272 (41): 25737–42. doi:10.1074/jbc.272.41.25737. PMID 9325300.  
  • Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.  
  • Hoshino K, Tsutsui H, Kawai T, et al. (1999). "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.". J. Immunol. 162 (9): 5041–4. PMID 10227969.  
  • Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.". J. Immunol. 165 (4): 1933–8. PMID 10925275.  
  • Kumar S, Hanning CR, Brigham-Burke MR, et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.". Cytokine 18 (2): 61–71. doi:10.1006/cyto.2002.0873. PMID 12096920.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gutzmer R, Langer K, Mommert S, et al. (2004). "Human dendritic cells express the IL-18R and are chemoattracted to IL-18.". J. Immunol. 171 (12): 6363–71. PMID 14662834.  
  • Azam T, Novick D, Bufler P, et al. (2004). "Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex.". J. Immunol. 171 (12): 6574–80. PMID 14662859.  
  • Towne JE, Garka KE, Renshaw BR, et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551.  
  • Cardoso SP, Keen L, Bidwell J (2004). "Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha.". Eur. J. Immunogenet. 31 (1): 27–9. doi:10.1111/j.1365-2370.2004.00441.x. PMID 15009178.  
  • Reddy SA, Lin YF, Huang HJ, et al. (2004). "The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation.". Biochem. Biophys. Res. Commun. 316 (4): 1022–8. doi:10.1016/j.bbrc.2004.02.155. PMID 15044087.  
  • Yoon- DY, Cho YS, Park JW, et al. (2005). "Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor.". Clin. Chem. Lab. Med. 42 (5): 499–506. doi:10.1515/CCLM.2004.085. PMID 15202785.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Sahar S, Dwarakanath RS, Reddy MA, et al. (2005). "Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis.". Circ. Res. 96 (10): 1064–71. doi:10.1161/01.RES.0000168210.10358.f4. PMID 15860756.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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