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Interleukin 18 receptor accessory protein
Symbols IL18RAP; ACPL; CDw218b; MGC120589; MGC120590
External IDs OMIM604509 MGI1338888 HomoloGene2859 GeneCards: IL18RAP Gene
RNA expression pattern
PBB GE IL18RAP 207072 at tn.png
More reference expression data
Species Human Mouse
Entrez 8807 16174
Ensembl ENSG00000115607 ENSMUSG00000026068
UniProt O95256 Q0VBK3
RefSeq (mRNA) NM_003853 NM_010553
RefSeq (protein) NP_003844 NP_034683
Location (UCSC) Chr 2:
102.4 - 102.44 Mb
Chr 1:
40.46 - 40.49 Mb
PubMed search [1] [2]

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.[1][2]



The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.[1]

Disease association

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.[3]

See also


  1. ^ a b "Entrez Gene: IL18RAP interleukin 18 receptor accessory protein".  
  2. ^ Born TL, Thomassen E, Bird TA, Sims JE (November 1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.  
  3. ^ Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA (April 2008). "Newly identified genetic risk variants for celiac disease related to the immune response". Nat. Genet. 40 (4): 395–402. doi:10.1038/ng.102. PMID 18311140.  

Further reading

  • Born TL, Thomassen E, Bird TA, Sims JE (1998). "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling.". J. Biol. Chem. 273 (45): 29445–50. doi:10.1074/jbc.273.45.29445. PMID 9792649.  
  • Sareneva T, Julkunen I, Matikainen S (2000). "IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.". J. Immunol. 165 (4): 1933–8. PMID 10925275.  
  • Mee JB, Alam Y, Groves RW (2000). "Human keratinocytes constitutively produce but do not process interleukin-18.". Br. J. Dermatol. 143 (2): 330–6. doi:10.1046/j.1365-2133.2000.03759.x. PMID 10951141.  
  • Debets R, Timans JC, Churakowa T, et al. (2000). "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.". J. Immunol. 165 (9): 4950–6. PMID 11046021.  
  • Salvati VM, MacDonald TT, Bajaj-Elliott M, et al. (2002). "Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease.". Gut 50 (2): 186–90. doi:10.1136/gut.50.2.186. PMID 11788557.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fukushima K, Ikehara Y, Yamashita K (2005). "Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.". J. Biol. Chem. 280 (18): 18056–62. doi:10.1074/jbc.M413297200. PMID 15760905.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Fiszer D, Rozwadowska N, Rychlewski L, et al. (2008). "Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues.". Cytokine 39 (3): 178–83. doi:10.1016/j.cyto.2007.07.186. PMID 17897836.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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