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Interleukin 3 receptor, alpha (low affinity)
Identifiers
Symbols IL3RA; CD123; IL3R; IL3RAY; IL3RX; IL3RY; MGC34174; hIL-3Ra
External IDs OMIM308385 MGI96553 HomoloGene48088 GeneCards: IL3RA Gene
RNA expression pattern
PBB GE IL3RA 206148 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3563 16188
Ensembl ENSG00000185291 ENSMUSG00000068758
UniProt P26951 P26952
RefSeq (mRNA) NM_002183 XM_983840
RefSeq (protein) NP_002174 XP_988934
Location (UCSC) Chr X:
1.42 - 1.46 Mb
Chr 14:
13.14 - 13.15 Mb
PubMed search [1] [2]

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.[1]

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.[1]

Contents

Interactions

IL3RA has been shown to interact with Interleukin 3.[2][3]

See also

References

  1. ^ a b "Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3563.  
  2. ^ Stomski, F C; Sun Q, Bagley C J, Woodcock J, Goodall G, Andrews R K, Berndt M C, Lopez A F (Jun. 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. (UNITED STATES) 16 (6): 3035–46. ISSN 0270-7306. PMID 8649415.  
  3. ^ Woodcock, J M; Zacharakis B, Plaetinck G, Bagley C J, Qiyu S, Hercus T R, Tavernier J, Lopez A F (Nov. 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. (ENGLAND) 13 (21): 5176–85. ISSN 0261-4189. PMID 7957082.  

Further reading

  • Hara T, Miyajima A (1997). "Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis.". Stem Cells 14 (6): 605–18. PMID 8948019.  
  • Testa U, Riccioni R, Diverio D, et al. (2004). "Interleukin-3 receptor in acute leukemia.". Leukemia 18 (2): 219–26. doi:10.1038/sj.leu.2403224. PMID 14671644.  
  • Kitamura T, Sato N, Arai K, Miyajima A (1991). "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors.". Cell 66 (6): 1165–74. doi:10.1016/0092-8674(91)90039-2. PMID 1833064.  
  • Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.". Oncogene 11 (4): 619–25. PMID 7651724.  
  • Yoshimura A, Ohkubo T, Kiguchi T, et al. (1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.". Embo J. 14 (12): 2816–26. PMID 7796808.  
  • Kosugi H, Nakagawa Y, Hotta T, et al. (1995). "Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor.". Biochem. Biophys. Res. Commun. 208 (1): 360–7. doi:10.1006/bbrc.1995.1346. PMID 7887951.  
  • Woodcock JM, Zacharakis B, Plaetinck G, et al. (1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.". Embo J. 13 (21): 5176–85. PMID 7957082.  
  • Kremer E, Baker E, D'Andrea RJ, et al. (1993). "A cytokine receptor gene cluster in the X-Y pseudoautosomal region?". Blood 82 (1): 22–8. PMID 8100720.  
  • Milatovich A, Kitamura T, Miyajima A, Francke U (1993). "Gene for the alpha-subunit of the human interleukin-3 receptor (IL3RA) localized to the X-Y pseudoautosomal region.". Am. J. Hum. Genet. 53 (5): 1146–53. PMID 8213838.  
  • Macardle PJ, Chen Z, Shih CY, et al. (1996). "Characterization of human leucocytes bearing the IL-3 receptor.". Cell. Immunol. 168 (1): 59–68. doi:10.1006/cimm.1996.0049. PMID 8599840.  
  • Stomski FC, Sun Q, Bagley CJ, et al. (1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.". Mol. Cell. Biol. 16 (6): 3035–46. PMID 8649415.  
  • Bagley CJ, Phillips J, Cambareri B, et al. (1997). "A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.". J. Biol. Chem. 271 (50): 31922–8. doi:10.1074/jbc.271.50.31922. PMID 8943237.  
  • Klein BK, Feng Y, McWherter CA, et al. (1997). "The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling.". J. Biol. Chem. 272 (36): 22630–41. doi:10.1074/jbc.272.36.22630. PMID 9278420.  
  • Wang P, Wu P, Cheewatrakoolpong B, et al. (1998). "Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils.". J. Immunol. 160 (9): 4427–32. PMID 9574547.  
  • Res PC, Couwenberg F, Vyth-Dreese FA, Spits H (1999). "Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus.". Blood 94 (8): 2647–57. PMID 10515868.  
  • Jahnsen FL, Lund-Johansen F, Dunne JF, et al. (2000). "Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy.". J. Immunol. 165 (7): 4062–8. PMID 11034417.  
  • Heinemann A, Hartnell A, Stubbs VE, et al. (2001). "Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling.". J. Immunol. 165 (12): 7224–33. PMID 11120855.  
  • Carr PD, Gustin SE, Church AP, et al. (2001). "Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration.". Cell 104 (2): 291–300. doi:10.1016/S0092-8674(01)00213-6. PMID 11207369.  
  • Kunitani H, Shimizu Y, Murata H, et al. (2002). "Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases.". J. Hepatol. 36 (6): 734–41. doi:10.1016/S0168-8278(02)00062-4. PMID 12044522.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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