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ILF2: Wikis


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Interleukin enhancer binding factor 2, 45kDa
Symbols ILF2; MGC8391; NF45; PRO3063
External IDs OMIM603181 MGI1915031 HomoloGene26894 GeneCards: ILF2 Gene
Species Human Mouse
Entrez 3608 67781
Ensembl ENSG00000143621 ENSMUSG00000001016
UniProt Q12905 Q3UXI9
RefSeq (mRNA) NM_004515 NM_026374
RefSeq (protein) NP_004506 NP_080650
Location (UCSC) Chr 1:
151.9 - 151.91 Mb
Chr 3:
90.56 - 90.57 Mb
PubMed search [1] [2]

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[1][2]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[2]



ILF2 has been shown to interact with CDC5L[3] and DNA-PKcs.[4]


  1. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B (Sep 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". J Biol Chem 269 (32): 20691–9. PMID 7519613.  
  2. ^ a b "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".  
  3. ^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec. 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMID 11101529.  
  4. ^ Ting, N S; Kao P N, Chan D W, Lintott L G, Lees-Miller S P (Jan. 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. (UNITED STATES) 273 (4): 2136–45. ISSN 0021-9258. PMID 9442054.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Marcoulatos P, Koussidis G, Mamuris Z, et al. (1997). "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates.". J. Interferon Cytokine Res. 16 (12): 1035–8. PMID 8974006.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Ting NS, Kao PN, Chan DW, et al. (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.". J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.  
  • Langland JO, Kao PN, Jacobs BL (1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR.". Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.  
  • Satoh M, Shaheen VM, Kao PN, et al. (2000). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.". J. Biol. Chem. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.  
  • Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". Embo J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMID 11101529.  
  • Parker LM, Fierro-Monti I, Mathews MB (2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase.". J. Biol. Chem. 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.  
  • Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.". Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMID 11739746.  
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.  
  • Shin HJ, Kim SS, Cho YH, et al. (2002). "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA.". Arch. Virol. 147 (3): 471–91. doi:10.1007/s007050200001. PMID 11958450.  
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMID 14559993.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.  
  • Zhao G, Shi L, Qiu D, et al. (2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function.". Exp. Cell Res. 305 (2): 312–23. doi:10.1016/j.yexcr.2004.12.030. PMID 15817156.  
  • Nie Y, Ding L, Kao PN, et al. (2005). "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing.". Mol. Cell. Biol. 25 (16): 6956–63. doi:10.1128/MCB.25.16.6956-6963.2005. PMID 16055709.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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