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Interleukin enhancer binding factor 3, 90kDa
Identifiers
Symbols ILF3; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4; NF-AT-90; NF90; NFAR; NFAR-1; TCP80
External IDs OMIM603182 MGI1339973 HomoloGene7785 GeneCards: ILF3 Gene
RNA expression pattern
PBB GE ILF3 211375 s at tn.png
PBB GE ILF3 208930 s at tn.png
PBB GE ILF3 217805 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3609 16201
Ensembl ENSG00000129351 ENSMUSG00000032178
UniProt Q12906 Q3UD30
RefSeq (mRNA) NM_004516 NM_001042707
RefSeq (protein) NP_004507 NP_001036172
Location (UCSC) Chr 19:
10.63 - 10.66 Mb
Chr 9:
21.14 - 21.16 Mb
PubMed search [1] [2]

Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene.[1][2]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene.[3]

Contents

Interactions

ILF3 has been shown to interact with XPO5,[4] FUS,[5] Protein kinase R,[5][6][7][8] PRMT1[9][10] and DNA-PKcs.[11]

References

  1. ^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B (Sep 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". J Biol Chem 269 (32): 20691–9. PMID 7519613.  
  2. ^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell 7 (9): 1455–69. PMID 8885239.  
  3. ^ "Entrez Gene: ILF3 interleukin enhancer binding factor 3, 90kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3609.  
  4. ^ Brownawell, Amy M; Macara Ian G (Jan. 2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". J. Cell Biol. (United States) 156 (1): 53–64. doi:10.1083/jcb.200110082. ISSN 0021-9525. PMID 11777942.  
  5. ^ a b Saunders, L R; Perkins D J, Balachandran S, Michaels R, Ford R, Mayeda A, Barber G N (Aug. 2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR". J. Biol. Chem. (United States) 276 (34): 32300–12. doi:10.1074/jbc.M104207200. ISSN 0021-9258. PMID 11438536.  
  6. ^ Langland, J O; Kao P N, Jacobs B L (May. 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry (UNITED STATES) 38 (19): 6361–8. doi:10.1021/bi982410u. ISSN 0006-2960. PMID 10320367.  
  7. ^ Parker, L M; Fierro-Monti I, Mathews M B (Aug. 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". J. Biol. Chem. (United States) 276 (35): 32522–30. doi:10.1074/jbc.M104408200. ISSN 0021-9258. PMID 11438540.  
  8. ^ Patel, R C; Vestal D J, Xu Z, Bandyopadhyay S, Guo W, Erme S M, Williams B R, Sen G C (Jul. 1999). "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR". J. Biol. Chem. (UNITED STATES) 274 (29): 20432–7. ISSN 0021-9258. PMID 10400669.  
  9. ^ Tang, J; Kao P N, Herschman H R (Jun. 2000). "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3". J. Biol. Chem. (UNITED STATES) 275 (26): 19866–76. doi:10.1074/jbc.M000023200. ISSN 0021-9258. PMID 10749851.  
  10. ^ Lee, Jaeho; Bedford Mark T (Mar. 2002). "PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays". EMBO Rep. (England) 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. ISSN 1469-221X. PMID 11850402.  
  11. ^ Ting, N S; Kao P N, Chan D W, Lintott L G, Lees-Miller S P (Jan. 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. (UNITED STATES) 273 (4): 2136–45. ISSN 0021-9258. PMID 9442054.  

Further reading

  • St Johnston D, Brown NH, Gall JG, Jantsch M (1992). "A conserved double-stranded RNA-binding domain.". Proc. Natl. Acad. Sci. U.S.A. 89 (22): 10979–83. doi:10.1073/pnas.89.22.10979. PMID 1438302.  
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.  
  • Ting NS, Kao PN, Chan DW, et al. (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.". J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.  
  • Marcoulatos P, Avgerinos E, Tsantzalos DV, Vamvakopoulos NC (1998). "Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates.". J. Interferon Cytokine Res. 18 (5): 351–5. PMID 9620363.  
  • Aoki Y, Zhao G, Qiu D, et al. (1999). "CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku.". Am. J. Physiol. 275 (6 Pt 1): L1164–72. PMID 9843854.  
  • Langland JO, Kao PN, Jacobs BL (1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR.". Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.  
  • Patel RC, Vestal DJ, Xu Z, et al. (1999). "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.". J. Biol. Chem. 274 (29): 20432–7. doi:10.1074/jbc.274.29.20432. PMID 10400669.  
  • Satoh M, Shaheen VM, Kao PN, et al. (2000). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.". J. Biol. Chem. 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.  
  • Xu YH, Grabowski GA (2000). "Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs.". Mol. Genet. Metab. 68 (4): 441–54. doi:10.1006/mgme.1999.2934. PMID 10607473.  
  • Coolidge CJ, Patton JG (2000). "A new double-stranded RNA-binding protein that interacts with PKR.". Nucleic Acids Res. 28 (6): 1407–17. doi:10.1093/nar/28.6.1407. PMID 10684936.  
  • Tang J, Kao PN, Herschman HR (2000). "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3.". J. Biol. Chem. 275 (26): 19866–76. doi:10.1074/jbc.M000023200. PMID 10749851.  
  • Saunders LR, Jurecic V, Barber GN (2001). "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13.". Genomics 71 (2): 256–9. doi:10.1006/geno.2000.6423. PMID 11161820.  
  • Duchange N, Pidoux J, Camus E, Sauvaget D (2001). "Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene.". Gene 261 (2): 345–53. doi:10.1016/S0378-1119(00)00495-9. PMID 11167023.  
  • Saunders LR, Perkins DJ, Balachandran S, et al. (2001). "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.". J. Biol. Chem. 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.  
  • Parker LM, Fierro-Monti I, Mathews MB (2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase.". J. Biol. Chem. 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.  
  • Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.". Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMID 11739746.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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